4’-methyl-2’-(Quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

Hamad H. Al Mamari; Anfal Al Hasani

doi:10.3390/M1132

4’-methyl-2’-(Quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

Hamad H. Al Mamari^*, Anfal Al Hasani

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

In this short note communication, we report the synthesis of a novel amide 4’-methyl-2’-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester by the Ru-catalyzed C(sp²)-H bond arylation reaction. The catalytic C-H bond functionalization reaction was employed, amongst other reaction reagents and conditions, [RuCl₂(p-cymene)]₂ as a precatalyst and (p-tol)₃P as a ligand. The arylation product was characterized by various spectroscopic methods (¹H NMR,¹³C NMR, IR, GC-MS, and IR spectroscopy), and its composition was confirmed by elemental analysis.

Original language	English
Article number	M1132
Journal	MolBank
Volume	2020
Issue number	2
DOIs	https://doi.org/10.3390/M1132
Publication status	Published - May 2020

Keywords

Benzamides
Bidentate directing groups
C-H bond functionalization
Catalysis
Chelation assistance
Organic synthesis

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/M1132

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@article{326543b9031c411f83d7a598d29f0f93,

title = "4{\textquoteright}-methyl-2{\textquoteright}-(Quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester",

abstract = "In this short note communication, we report the synthesis of a novel amide 4{\textquoteright}-methyl-2{\textquoteright}-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester by the Ru-catalyzed C(sp2)-H bond arylation reaction. The catalytic C-H bond functionalization reaction was employed, amongst other reaction reagents and conditions, [RuCl2(p-cymene)]2 as a precatalyst and (p-tol)3P as a ligand. The arylation product was characterized by various spectroscopic methods (1H NMR,13C NMR, IR, GC-MS, and IR spectroscopy), and its composition was confirmed by elemental analysis.",

keywords = "Benzamides, Bidentate directing groups, C-H bond functionalization, Catalysis, Chelation assistance, Organic synthesis",

author = "{Al Mamari}, {Hamad H.} and {Al Hasani}, Anfal",

note = "Funding Information: Funding: The research work is funded by the Sultan Qaboos University Research Fund Grant (RF/SCI/CHEM/19/01). Funding Information: Acknowledgments: The funding of this work by Sultan Qaboos University is gratefully acknowledged. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = may,

doi = "10.3390/M1132",

language = "English",

volume = "2020",

journal = "MolBank",

issn = "1422-8599",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - 4’-methyl-2’-(Quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

AU - Al Mamari, Hamad H.

AU - Al Hasani, Anfal

N1 - Funding Information: Funding: The research work is funded by the Sultan Qaboos University Research Fund Grant (RF/SCI/CHEM/19/01). Funding Information: Acknowledgments: The funding of this work by Sultan Qaboos University is gratefully acknowledged. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/5

Y1 - 2020/5

N2 - In this short note communication, we report the synthesis of a novel amide 4’-methyl-2’-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester by the Ru-catalyzed C(sp2)-H bond arylation reaction. The catalytic C-H bond functionalization reaction was employed, amongst other reaction reagents and conditions, [RuCl2(p-cymene)]2 as a precatalyst and (p-tol)3P as a ligand. The arylation product was characterized by various spectroscopic methods (1H NMR,13C NMR, IR, GC-MS, and IR spectroscopy), and its composition was confirmed by elemental analysis.

AB - In this short note communication, we report the synthesis of a novel amide 4’-methyl-2’-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester by the Ru-catalyzed C(sp2)-H bond arylation reaction. The catalytic C-H bond functionalization reaction was employed, amongst other reaction reagents and conditions, [RuCl2(p-cymene)]2 as a precatalyst and (p-tol)3P as a ligand. The arylation product was characterized by various spectroscopic methods (1H NMR,13C NMR, IR, GC-MS, and IR spectroscopy), and its composition was confirmed by elemental analysis.

KW - Benzamides

KW - Bidentate directing groups

KW - C-H bond functionalization

KW - Catalysis

KW - Chelation assistance

KW - Organic synthesis

UR - http://www.scopus.com/inward/record.url?scp=85085881608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85085881608&partnerID=8YFLogxK

U2 - 10.3390/M1132

DO - 10.3390/M1132

M3 - Comment/debate

AN - SCOPUS:85085881608

SN - 1422-8599

VL - 2020

JO - MolBank

JF - MolBank

IS - 2

M1 - M1132

ER -

4’-methyl-2’-(Quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester

Abstract

Keywords

ASJC Scopus subject areas

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