TY - JOUR
T1 - 3. Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania
AU - Babiker, H. A.
AU - Ranford-Cartwright, L. C.
AU - Walliker, D.
N1 - Funding Information:
Acknowledgements We thank the staff of the Ifakara Centre, National Institute of Medical Research, Tanzania and the malaria research group of the Swiss Trouical Institute. Basel. for their helo and co-oo-eration during the course of this work. We are g;ateful to the Medical Research Council of Great Britain and the Wellcome Trust for support.
PY - 1999
Y1 - 1999
N2 - Plasmodium falciparum parasites exist as genetically distinct haploid clones in infected people. In the Kilombero valley in south-east Tanzania, at least 85% of the inhabitants of Michenga village harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 P. falciparum clones at any one time, with a mean of 3.5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0.33.
AB - Plasmodium falciparum parasites exist as genetically distinct haploid clones in infected people. In the Kilombero valley in south-east Tanzania, at least 85% of the inhabitants of Michenga village harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 P. falciparum clones at any one time, with a mean of 3.5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0.33.
KW - Genetics
KW - Inbreeding
KW - Malaria
KW - Multiple infection
KW - Plasmodium falciparum
KW - Tanzania
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U2 - 10.1016/S0035-9203(99)90321-8
DO - 10.1016/S0035-9203(99)90321-8
M3 - Article
C2 - 10450420
AN - SCOPUS:0033069470
SN - 0035-9203
VL - 93
SP - 11
EP - 14
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - SUPPL. 1
ER -
