3. Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania

H. A. Babiker*, L. C. Ranford-Cartwright, D. Walliker

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Plasmodium falciparum parasites exist as genetically distinct haploid clones in infected people. In the Kilombero valley in south-east Tanzania, at least 85% of the inhabitants of Michenga village harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 P. falciparum clones at any one time, with a mean of 3.5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0.33.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume93
Issue numberSUPPL. 1
Publication statusPublished - 1999

Keywords

  • Genetics
  • Inbreeding
  • Malaria
  • Multiple infection
  • Plasmodium falciparum
  • Tanzania

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

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