Abstract
1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.
Original language | English |
---|---|
Pages (from-to) | 557-560 |
Number of pages | 4 |
Journal | Journal of Radioanalytical and Nuclear Chemistry |
Volume | 267 |
Issue number | 3 |
DOIs | |
Publication status | Published - May 2006 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Pollution
- Spectroscopy
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis