1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil; M. Übele; W. Ehrlichmann; W. Voelter; H. J. Machulla

doi:10.1007/s10967-006-0086-9

1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil, M. Übele, W. Ehrlichmann, W. Voelter, H. J. Machulla

Chemistry

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and ¹⁸F labeling gave the corresponding markers in 70-82% radiochemical yield.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	267
Issue number	3
DOIs	https://doi.org/10.1007/s10967-006-0086-9
Publication status	Published - May 2006

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ASJC Scopus subject areas

Analytical Chemistry
Inorganic Chemistry
Nuclear Energy and Engineering

Cite this

Abdel-Jalil, R. J., Übele, M., Ehrlichmann, W., Voelter, W., & Machulla, H. J. (2006). 1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers. Journal of Radioanalytical and Nuclear Chemistry, 267(3), 557-560. https://doi.org/10.1007/s10967-006-0086-9

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10.1007/s10967-006-0086-9