1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil, M. Übele, W. Ehrlichmann, W. Voelter, H. J. Machulla

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

Original languageEnglish
Pages (from-to)557-560
Number of pages4
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume267
Issue number3
DOIs
Publication statusPublished - May 2006

Fingerprint

Nitroimidazoles
Glycols
Labeling
Substitution reactions
Fluorides
azomycin
Hypoxia

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this

1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers. / Abdel-Jalil, R. J.; Übele, M.; Ehrlichmann, W.; Voelter, W.; Machulla, H. J.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 267, No. 3, 05.2006, p. 557-560.

Research output: Contribution to journalArticle

Abdel-Jalil, R. J. ; Übele, M. ; Ehrlichmann, W. ; Voelter, W. ; Machulla, H. J. / 1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers. In: Journal of Radioanalytical and Nuclear Chemistry. 2006 ; Vol. 267, No. 3. pp. 557-560.
@article{8a2bf25e6ed54d5b9c621551bca60615,
title = "1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers",
abstract = "1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82{\%} radiochemical yield.",
author = "Abdel-Jalil, {R. J.} and M. {\"U}bele and W. Ehrlichmann and W. Voelter and Machulla, {H. J.}",
year = "2006",
month = "5",
doi = "10.1007/s10967-006-0086-9",
language = "English",
volume = "267",
pages = "557--560",
journal = "Journal of Radioanalytical Chemistry",
issn = "0022-4081",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - 1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

AU - Abdel-Jalil, R. J.

AU - Übele, M.

AU - Ehrlichmann, W.

AU - Voelter, W.

AU - Machulla, H. J.

PY - 2006/5

Y1 - 2006/5

N2 - 1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

AB - 1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

UR - http://www.scopus.com/inward/record.url?scp=33344471085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33344471085&partnerID=8YFLogxK

U2 - 10.1007/s10967-006-0086-9

DO - 10.1007/s10967-006-0086-9

M3 - Article

VL - 267

SP - 557

EP - 560

JO - Journal of Radioanalytical Chemistry

JF - Journal of Radioanalytical Chemistry

SN - 0022-4081

IS - 3

ER -