1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil; M. Übele; W. Ehrlichmann; W. Voelter; H. J. Machulla

doi:10.1007/s10967-006-0086-9

1-[¹⁸F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

R. J. Abdel-Jalil^*, M. Übele, W. Ehrlichmann, W. Voelter, H. J. Machulla

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and ¹⁸F labeling gave the corresponding markers in 70-82% radiochemical yield.

Original language	English
Pages (from-to)	557-560
Number of pages	4
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	267
Issue number	3
DOIs	https://doi.org/10.1007/s10967-006-0086-9
Publication status	Published - May 2006
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10967-006-0086-9

Cite this

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title = "1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers",

abstract = "1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.",

author = "Abdel-Jalil, {R. J.} and M. {\"U}bele and W. Ehrlichmann and W. Voelter and Machulla, {H. J.}",

note = "Funding Information: Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks DAAD (Bonn, Germany) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgemeinschaft (DFG), Grant Number PI 242/3-1.",

year = "2006",

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doi = "10.1007/s10967-006-0086-9",

language = "English",

volume = "267",

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T1 - 1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers

AU - Abdel-Jalil, R. J.

AU - Übele, M.

AU - Ehrlichmann, W.

AU - Voelter, W.

AU - Machulla, H. J.

N1 - Funding Information: Financial support, provided by the Hashemite University, is greatly acknowledged. R.A.-J thanks DAAD (Bonn, Germany) for a research visit fellowship. This work is part of a research project funded by Deutsche Forschungsgemeinschaft (DFG), Grant Number PI 242/3-1.

PY - 2006/5

Y1 - 2006/5

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AB - 1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2- fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2- fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence. Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and 18F labeling gave the corresponding markers in 70-82% radiochemical yield.

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