σ-Acetylide complexes for biomedical applications: Features, challenges and future directions

Ashanul Haque, Rayya A. Al-Balushi, Muhammad S. Khan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Mono-, di- and polynuclear metal alkynyl or σ-acetylide complexes have attracted a great deal of interest due to their multi-dimensional applications. In the past few decades, several small to medium sized neutral and charged metal acetylides have been synthesized and assessed for various biomedical applications. This review explores the progress made in the design and development of rigid-rod type η1-σ-alkynyl complexes for therapeutic (viz. anticancer, antibacterial) and diagnostic (viz. enzymes or proteins imaging) purposes. The features that make metal acetylides unique for bio-applications, their diversity as biomaterials, and future potential for clinical usage have been reviewed. Although few challenges exist with this class of materials (which we have identified and discussed in the review), metal acetylides have a bright future in different branches of medical science and hold promise as next generation biomaterials.

Original languageEnglish
Pages (from-to)95-106
Number of pages12
JournalJournal of Organometallic Chemistry
Volume897
DOIs
Publication statusPublished - Oct 1 2019

Keywords

  • Anticancer
  • Biomedical applications
  • Imaging
  • Metal acetylides

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'σ-Acetylide complexes for biomedical applications: Features, challenges and future directions'. Together they form a unique fingerprint.

Cite this