TY - JOUR
T1 - σ-Acetylide complexes for biomedical applications
T2 - Features, challenges and future directions
AU - Haque, Ashanul
AU - Al-Balushi, Rayya A.
AU - Khan, Muhammad S.
N1 - Funding Information:
AH acknowledges the Department of Chemistry, University of Hail, Kingdom of Saudi Arabia for providing infrastructure support during the preparation of this manuscript. MSK acknowledges the British Petroleum, Oman (Grant No. EG/SQU-BP/SCI/CHEM/19/01 ) and The Research Council (TRC), Oman (Project No. BFP/RGP/EI/18/057 ) for support during the preparation of this review manuscript.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Mono-, di- and polynuclear metal alkynyl or σ-acetylide complexes have attracted a great deal of interest due to their multi-dimensional applications. In the past few decades, several small to medium sized neutral and charged metal acetylides have been synthesized and assessed for various biomedical applications. This review explores the progress made in the design and development of rigid-rod type η1-σ-alkynyl complexes for therapeutic (viz. anticancer, antibacterial) and diagnostic (viz. enzymes or proteins imaging) purposes. The features that make metal acetylides unique for bio-applications, their diversity as biomaterials, and future potential for clinical usage have been reviewed. Although few challenges exist with this class of materials (which we have identified and discussed in the review), metal acetylides have a bright future in different branches of medical science and hold promise as next generation biomaterials.
AB - Mono-, di- and polynuclear metal alkynyl or σ-acetylide complexes have attracted a great deal of interest due to their multi-dimensional applications. In the past few decades, several small to medium sized neutral and charged metal acetylides have been synthesized and assessed for various biomedical applications. This review explores the progress made in the design and development of rigid-rod type η1-σ-alkynyl complexes for therapeutic (viz. anticancer, antibacterial) and diagnostic (viz. enzymes or proteins imaging) purposes. The features that make metal acetylides unique for bio-applications, their diversity as biomaterials, and future potential for clinical usage have been reviewed. Although few challenges exist with this class of materials (which we have identified and discussed in the review), metal acetylides have a bright future in different branches of medical science and hold promise as next generation biomaterials.
KW - Anticancer
KW - Biomedical applications
KW - Imaging
KW - Metal acetylides
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U2 - 10.1016/j.jorganchem.2019.06.026
DO - 10.1016/j.jorganchem.2019.06.026
M3 - Review article
AN - SCOPUS:85068266911
SN - 0022-328X
VL - 897
SP - 95
EP - 106
JO - Journal of Organometallic Chemistry
JF - Journal of Organometallic Chemistry
ER -