DATE PALM FRUITS: EFFECT ON PARKINSON'S DISEASE MODELS

  • Essa, Mohamed Musthafa (PI)

Project: Other project

Project Details

Description

Parkinson's disease (PD), a second neurodegenerative disease and it is considered as progressive movement disorder. The causes of PD is by diverse pathological conditions resulting from dysfunction of the ubiquitin-proteasome system (UPS), mitochondria, and oxidative stress leading to preferential nigral dopamine (DA) neuron degeneration in the substantia nigra. Today, only symptomatic and non-neuro-protective therapies are available for the treatment of PD. Current treatment strategies are having short term retention and costly. Therefore it is important to focus on neuro-protective therapy using alternative methods. Objective: Reports suggests that dietary supplementation with food groups such as fruits, tree nuts, and vegetables rich in flavonoids, polyphenols, vitamins, micronutrients, and minerals improves cognition and memory. Till now, there are no studies were reported on the effect of date palm fruits (DPF) grown in Oman against Parkinson?s disease models. To fill the information gap the current study is planned to find the effect of DPF experimental PD models. Methods: Effect of date palm fruits on biochemical changes during rotenone induced neurotoxicity in SH-SY-5Y cell lines in vitro will be done. The effect of date palm fruits on behavioral and behavioral alterations in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) induced Parkinson?s disease in C57BL/6 mice model (in vivo) will be done. Outcome: Fig fruits have been reported to offer neuro-protection to other neurodegenerative diseases and this study will show whether the date palm fruits grown in Oman has neuro-protective effect on experimental PD. The outcome of this study may give a lead for novel therapeutic approach for the PD treatment.

Layman's description

Parkinson's disease (PD), a second neurodegenerative disease and it is considered as progressive movement disorder. The causes of PD is by diverse pathological conditions resulting from dysfunction of the ubiquitin-proteasome system (UPS), mitochondria, and oxidative stress leading to preferential nigral dopamine (DA) neuron degeneration in the substantia nigra. Today, only symptomatic and non-neuro-protective therapies are available for the treatment of PD. Current treatment strategies are having short term retention and costly. Therefore it is important to focus on neuro-protective therapy using alternative methods. Objective: Reports suggests that dietary supplementation with food groups such as fruits, tree nuts, and vegetables rich in flavonoids, polyphenols, vitamins, micronutrients, and minerals improves cognition and memory. Till now, there are no studies were reported on the effect of date palm fruits (DPF) grown in Oman against Parkinson?s disease models. To fill the information gap the current study is planned to find the effect of DPF experimental PD models. Methods: Effect of date palm fruits on biochemical changes during rotenone induced neurotoxicity in SH-SY-5Y cell lines in vitro will be done. The effect of date palm fruits on behavioral and behavioral alterations in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) induced Parkinson?s disease in C57BL/6 mice model (in vivo) will be done. Outcome: Fig fruits have been reported to offer neuro-protection to other neurodegenerative diseases and this study will show whether the date palm fruits grown in Oman has neuro-protective effect on experimental PD. The outcome of this study may give a lead for novel therapeutic approach for the PD treatment.
AcronymTTotP
StatusNot started

Keywords

  • Date palm fruits
  • Oxidative stress
  • Parkinson?s disease
  • Behavior
  • Oman

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