Fahad AL Zadjali

Dr.

  • 372 Citations
  • 9 h-Index
20072019
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Research Output 2007 2019

  • 372 Citations
  • 9 h-Index
  • 28 Article
  • 1 Letter
  • 1 Review article
2019

New derivatives of 11-keto-β-boswellic acid (KBA) induce apoptosis in breast and prostate cancers cells

Bani Araba, A., Ur Rehman, N., Al-Araimi, A., Al-Hashmi, S., Al-Shidhani, S., Csuk, R., Hussain, H., Al-Harrasi, A. & AL Zadjali, F., Jan 1 2019, In : Natural Product Research.

Research output: Contribution to journalArticle

keto acids
prostatic neoplasms
breast neoplasms
Prostatic Neoplasms
apoptosis

Tuberous sclerosis complex exhibits a new renal cystogenic mechanism

Bissler, J. J., AL Zadjali, F., Bridges, D., Astrinidis, A., Barone, S., Yao, Y., Redd, J. A. R., Siroky, B. J., Wang, Y., Finley, J. T., Rusiniak, M. E., Baumann, H., Zahedi, K., Gross, K. W. & Soleimani, M., Jan 1 2019, In : Physiological Reports. 7, 2, e13983.

Research output: Contribution to journalArticle

Tuberous Sclerosis
Kidney
Angiomyolipoma
Autosomal Dominant Polycystic Kidney
Neoplasms
2018
1 Citation (Scopus)

Homozygosity for FARSB mutation leads to Phe-tRNA synthetase-related disease of growth restriction, brain calcification, and interstitial lung disease

AL Zadjali, F., Al-Yahyaee, A., Al-Nabhani, M., Al-Mubaihsi, S., Gujjar, A., Raniga, S. & Al-Maawali, A., Oct 1 2018, In : Human Mutation. 39, 10, p. 1355-1359 5 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Interstitial Lung Diseases
Mutation
Brain
Growth
2 Citations (Scopus)

Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties

Barkia, I., Al Haj, L., Abdul Hamid, A., Zakaria, M., Saari, N. & AL Zadjali, F., Jan 1 2018, (Accepted/In press) In : International Journal of Food Science and Technology.

Research output: Contribution to journalArticle

Microalgae
Diatoms
antihypertensive agents
Bacillariophyceae
Antioxidants
7 Citations (Scopus)
Exome
Intellectual Disability
Computational Biology
Genetic Databases
Phenotype
2017
3 Citations (Scopus)

Isolation and identification of indigenous marine diatoms (Bacillariophyta) for biomass production in open raceway ponds

Barkia, I., Zadjali, F., Saari, N., Zakaria, M. H., Li, C. L., Witkowski, A. & Al-Haj, L., 2017, (Accepted/In press) In : Aquaculture Research.

Research output: Contribution to journalArticle

raceways
Bellerochea
Bacillariophyceae
biomass production
diatom
9 Citations (Scopus)

The ubiquitin ligase Cullin5 SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

Paul, I., Batth, T. S., Iglesias-Gato, D., Al-Araimi, A., Al-Haddabi, I., Alkharusi, A., Norstedt, G., Olsen, J. V., Zadjali, F. & Flores-Morales, A., Feb 20 2017, In : Scientific Reports. 7, 42800.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Transcriptional Activation
Ubiquitin-Protein Ligases
Gigantism
2016
2 Citations (Scopus)

Frequency of TLR4 (1063A/G and 1363C/T) polymorphisms in healthy and HIV-infected Omani individuals and their relationship to viral load and T cell count

Said, E. A., Al-Yafei, F., Zadjali, F., Al-Balushi, M. S., Hasson, S. S., Al-Mahroqi, S. H., Koh, C. Y., Al-Naamani, K., Al-Busaidi, J. Z., Idris, M. A., Balkhair, A. & Al-Jabri, A. A., Apr 4 2016, In : Genetics and Molecular Research. 15, 2, 15027671.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
Viral Load
Single Nucleotide Polymorphism
Cell Count
HIV
4 Citations (Scopus)
Dietary Supplements
Lipids
Pregnancy
Probiotics
Gestational Diabetes
5 Citations (Scopus)

Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme

Alkharusi, A., Yu, S., Landázuri, N., Zadjali, F., Davodi, B., Nyström, T., Gräslund, T., Rahbar, A. & Norstedt, G., 2016, In : Oncotarget. 7, 48, p. 79572-79583 12 p.

Research output: Contribution to journalArticle

Prolactin Receptors
Glioblastoma
Prolactin
Phosphorylation
Brain Neoplasms
3 Citations (Scopus)

Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice

Alkharusi, A., Mirecki-Garrido, M., Ma, Z., Zadjali, F., Flores-Morales, A., Nyström, T., Castrillo, A., Bjorklund, A., Norstedt, G. & Fernandez-Pérez, L., Apr 1 2016, In : Hormone Molecular Biology and Clinical Investigation. 26, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Streptozocin
Type 1 Diabetes Mellitus
Cytokines
Insulin
Experimental Diabetes Mellitus
2015
5 Citations (Scopus)

Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile adrenoceptor β2 polymorphisms among Omanis

Al-Balushi, K., Zadjali, F., Al-Sinani, S., Al-Zadjali, A. M. & Bayoumi, R., Nov 1 2015, In : Sultan Qaboos University Medical Journal. 15, 4, p. e486-e490

Research output: Contribution to journalArticle

Adrenergic Receptors
Single Nucleotide Polymorphism
Genotype
Oman
Linkage Disequilibrium
3 Citations (Scopus)

Proportion of night eating syndrome in Arab population of Oman

Zadjali, F., Al-Bulushi, A., AlHassani, F. & Al Hinai, M., Nov 25 2015, In : Journal of Eating Disorders. 3, 1, 43.

Research output: Contribution to journalLetter

Oman
Eating
Population
Obesity
Hyperphagia
59 Citations (Scopus)

Use of germ-free animal models in microbiota-related research

Al-Asmakh, M. & Zadjali, F., 2015, In : Journal of Microbiology and Biotechnology. 25, 10, p. 1583-1588 6 p., A001.

Research output: Contribution to journalArticle

Microbiota
Animal Models
Large Intestine
Research
Vitamins
2014
15 Citations (Scopus)
HIV Infections
Single Nucleotide Polymorphism
Cell Count
Genotype
HIV

Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population

Al-Mahruqi, S. H., Zadjali, F., Beja-Pereira, A., Koh, C. Y., Balkhair, A. & Al-Jabri, A. A., 2014, In : Genetics and Molecular Biology. 37, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

Alleles
Haplotypes
Population
Genes
Indian Ocean
1 Citation (Scopus)

HLA-A68 and HLA-B15 alleles correlate with poor immune response among AIDS patients on combined antiretroviral therapy

El-Beeli, M., Al-Mahrooqi, S. H., Youssef, R. M., Zadjali, F., Balkhair, A., Al-Balushi, M. S., Said, E. A., Hasson, S. S. & Al-Jabri, A. A., Feb 5 2014, (Accepted/In press) In : Human Immunology.

Research output: Contribution to journalArticle

HLA-B15 Antigen
Acquired Immunodeficiency Syndrome
Alleles
Viral Load
HIV-1
5 Citations (Scopus)

Low-density lipoprotein receptor gene mutation analysis and structure-function correlation in an Omani Arab family with familial hypercholesterolemia

Al-Rasadi, K., Al-Waili, K., Al-Zidi, W. A. M., Al-Abri, A. R., Al-Hinai, A. T., Al-Sabti, H. A., Al-Tobi, S., Al-Zakwani, I., Al-Zadjali, F., Al-Hashmi, K. & Banerjee, Y., Nov 12 2014, In : Angiology. 65, 10, p. 911-918 8 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
LDL Receptors
Mutation
Genes
Apolipoproteins B
2 Citations (Scopus)
CCR Receptors
Population
Genes
Chemokines
Ethnic Groups
3 Citations (Scopus)

Utility of large consanguineous family-based model for investigating the genetics of type 2 diabetes mellitus

Al-Sinani, S., Hassan, M. O., Zadjali, F., Al-Yahyaee, S., Albarwani, S., Rizvi, S., Jaju, D., Comuzzie, A., Voruganti, V. S. & Bayoumi, R., Sep 10 2014, In : Gene. 548, 1, p. 22-28 7 p.

Research output: Contribution to journalArticle

Genetic Models
Type 2 Diabetes Mellitus
Genome-Wide Association Study
Genes
Genotype
2013
18 Citations (Scopus)

Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study

Zadjali, F., AL-Yahyaee, S., Hassan, M. O., Albarwani, S. & Bayoumi, R. A., Sep 25 2013, In : Gene. 527, 2, p. 663-669 7 p.

Research output: Contribution to journalArticle

Adiponectin
Single Nucleotide Polymorphism
Obesity
Waist Circumference
Adipose Tissue
2012
11 Citations (Scopus)

Busulphan-cyclophosphamide cause endothelial injury, remodeling of resistance arteries and enhanced expression of endothelial nitric oxide synthase

Al-Hashmi, S., Boels, P. J. M., Zadjali, F., Sadeghi, B., Sällström, J., Hultenby, K., Hassan, Z., Arner, A. & Hassan, M., Jan 27 2012, In : PLoS One. 7, 1, e30897.

Research output: Contribution to journalArticle

Busulfan
cyclophosphamide
Nitric Oxide Synthase Type III
Cyclophosphamide
arteries
46 Citations (Scopus)

Gut microbial communities modulating brain development and function.

Al-Asmakh, M., Anuar, F., Zadjali, F., Rafter, J. & Pettersson, S., Jan 1 2012, In : Gut Microbes. 3, 4, p. 366-373 8 p.

Research output: Contribution to journalReview article

Brain
Microbiota
Cognition
Cues
34 Citations (Scopus)

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

Zadjali, F., Santana-Farre, R., Vesterlund, M., Carow, B., Mirecki-Garrido, M., Hernandez-Hernandez, I., Flodström-Tullberg, M., Parini, P., Rottenberg, M., Norstedt, G., Fernandez-Perez, L. & Flores-Morales, A., Aug 2012, In : FASEB Journal. 26, 8, p. 3282-3291 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Growth Hormone
Insulin Resistance
Fats
40 Citations (Scopus)

Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3

Kazi, J. U., Sun, J., Phung, B., Zadjali, F., Flores-Morales, A. & Rönnstrand, L., Oct 19 2012, In : Journal of Biological Chemistry. 287, 43, p. 36509-36517 9 p.

Research output: Contribution to journalArticle

Signal transduction
Tyrosine
Signal Transduction
Cytokines
Receptor Protein-Tyrosine Kinases
2011
2 Citations (Scopus)

Liver X receptor agonist downregulates growth hormone signaling in the liver

Zadjali, F., Flores-Morales, A., Zadjali, F., Norstedt, G., Zadjali, F., Santana-Farre, R., Mirecki-Garrido, M., Ellis, E. & Zadjali, F., 2011, In : Hormone Molecular Biology and Clinical Investigation. 8, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

Growth Hormone
Down-Regulation
STAT5 Transcription Factor
Liver
Sterol Regulatory Element Binding Protein 1
37 Citations (Scopus)

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase

Zadjali, F., Pike, A. C. W., Vesterlund, M., Sun, J., Wu, C., Li, S. S. C., Rönnstrand, L., Knapp, S., Bullock, A. N. & Flores-Morales, A., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 480-490 11 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Cytokines
Stem Cell Factor
src Homology Domains
42 Citations (Scopus)

The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels

Vesterlund, M., Zadjali, F., Persson, T., Nielsen, M. L., Kessler, B. M., Norstedt, G. & Flores-Morales, A., Sep 29 2011, In : PLoS One. 6, 9, e25358.

Research output: Contribution to journalArticle

Somatotropin Receptors
Ligases
ubiquitin
Ubiquitin
ligases
2009
8 Citations (Scopus)

Cocoa butter and safflower oil elicit different effects on hepatic gene expression and lipid metabolism in rats

Gustavsson, C., Parini, P., Ostojic, J., Cheung, L., Hu, J., Zadjali, F., Tahir, F., Brismar, K., Norstedt, G. & Tollet-Egnell, P., Nov 2009, In : Lipids. 44, 11, p. 1011-1027 17 p.

Research output: Contribution to journalArticle

Safflower Oil
Lipid Metabolism
Gene expression
Rats
Triglycerides
2007
5 Citations (Scopus)

N-acetyltransferase polymorphism among northern Sudanese

Al-Yahyaee, S., Gaffar, U., Al-Ameri, M. M., Qureshi, M., Zadjali, F., Ali, B. H. & Bayoumi, R., Aug 2007, In : Human Biology. 79, 4, p. 445-452 8 p.

Research output: Contribution to journalArticle

acetyltransferases
Acetyltransferases
single nucleotide polymorphism
Single Nucleotide Polymorphism
allele