TY - JOUR
T1 - Zinc nanoparticles induced brain lesions and behavioral changes in two tilapia species
AU - Afifi, Mohamed
AU - Abu Zinada, Osama A.
AU - Ali, Haytham
AU - Couderchet, Michel
N1 - Publisher Copyright:
© 2016, Japanese Journal of Veterinary Research. All rights reserved.
PY - 2016
Y1 - 2016
N2 - In this study, we investigated the induced behavioral changes and neuropathology of prolonged exposure to high doses of Zn-NPs in two species of tilapia, T. nilotica and T. zilli. Fish that were treated with 2000 µg Zn-NPs /L showed severe degenerative changes and vacuolation in the neuropil, particularly of the optic tectum, with congestion of the blood vessels of both the cerebral cortex and the meninx primitive. Loss of the Purkinje cell layer of the cerebellum was noticed as well. Fish showed behavioral changes that included loss of equilibrium, slower movement and swimming sideways. No significant differences were observed between T. nilotica and T. zilli in behavioral or pathological changes. Our results highlight the Zn-NPs neurotoxicity and its accompanied neuropathology and related behavioral changes in fish. More caution is needed during the usage of Zn-NPs to avoid possible deleterious impacts on human and animal health.
AB - In this study, we investigated the induced behavioral changes and neuropathology of prolonged exposure to high doses of Zn-NPs in two species of tilapia, T. nilotica and T. zilli. Fish that were treated with 2000 µg Zn-NPs /L showed severe degenerative changes and vacuolation in the neuropil, particularly of the optic tectum, with congestion of the blood vessels of both the cerebral cortex and the meninx primitive. Loss of the Purkinje cell layer of the cerebellum was noticed as well. Fish showed behavioral changes that included loss of equilibrium, slower movement and swimming sideways. No significant differences were observed between T. nilotica and T. zilli in behavioral or pathological changes. Our results highlight the Zn-NPs neurotoxicity and its accompanied neuropathology and related behavioral changes in fish. More caution is needed during the usage of Zn-NPs to avoid possible deleterious impacts on human and animal health.
KW - Behavioral alteration
KW - Nanoparticles
KW - Neuropathology
KW - Tilapia
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UR - http://www.scopus.com/inward/citedby.url?scp=84971459889&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84971459889
SN - 0047-1917
VL - 64
SP - S161-S166
JO - Japanese Journal of Veterinary Research
JF - Japanese Journal of Veterinary Research
ER -