TY - JOUR
T1 - West syndrome
T2 - A university hospital based study from Oman
AU - Koul, Roshan
AU - Chacko, Alexander
AU - Cherian, Elizabeth
PY - 2001
Y1 - 2001
N2 - Forty-four children (20 male: 24 female) with West syndrome (infantile spasms, mental retardation/regression and hypsarrhythmia) diagnosed at Sultan Qaboos University Hospital (Pediatric Neurology Division of the Department of Child Health) are reported, with thirty-four (77.3%) children constituting the symptomatic group. All children were followed up for an initial 1 year at this hospital. Thirty-seven cases (84%) still continue their follow-up with us. The age of onset ranged from 1 to 14 months (mean, 6.0 months). Developmental delay before the onset of infantile spasms was noted in 29 (65.9%) children. Brain computed tomography was abnormal in 29 (65.9%). Sodium valproate and vigabatrin were the most often used drugs, though other antiepileptic drugs were also used. Nine (24.5%) children achieved good seizure control, out of which five have normal development. Only one child could be weaned off antiepileptic drugs completely. There was one death in the whole series, related to aspiration pneumonia.
AB - Forty-four children (20 male: 24 female) with West syndrome (infantile spasms, mental retardation/regression and hypsarrhythmia) diagnosed at Sultan Qaboos University Hospital (Pediatric Neurology Division of the Department of Child Health) are reported, with thirty-four (77.3%) children constituting the symptomatic group. All children were followed up for an initial 1 year at this hospital. Thirty-seven cases (84%) still continue their follow-up with us. The age of onset ranged from 1 to 14 months (mean, 6.0 months). Developmental delay before the onset of infantile spasms was noted in 29 (65.9%) children. Brain computed tomography was abnormal in 29 (65.9%). Sodium valproate and vigabatrin were the most often used drugs, though other antiepileptic drugs were also used. Nine (24.5%) children achieved good seizure control, out of which five have normal development. Only one child could be weaned off antiepileptic drugs completely. There was one death in the whole series, related to aspiration pneumonia.
KW - Follow-up
KW - Hypsarrhythmia
KW - Infantile spasms
KW - Oman
KW - Vigabatrin
KW - West syndrome
UR - http://www.scopus.com/inward/record.url?scp=0034783159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034783159&partnerID=8YFLogxK
U2 - 10.1016/S0387-7604(01)00286-8
DO - 10.1016/S0387-7604(01)00286-8
M3 - Article
C2 - 11701261
AN - SCOPUS:0034783159
SN - 0387-7604
VL - 23
SP - 586
EP - 592
JO - Brain and Development
JF - Brain and Development
IS - 7
ER -