TY - JOUR
T1 - Warfarin pharmacogenetics
T2 - Polymorphisms of the CYP2C9, CYP4F2, and VKORC1 loci in a genetically admixed Omani population
AU - Pathare, Anil V.
AU - Al Zadjali, Shoaib
AU - Misquith, Rhea
AU - Alkindi, Salam S.
AU - Panjwani, Vinodh
AU - Lapoumeroulie, Claudine
AU - Pravin, Sahaya
AU - Paldi, Andras
AU - Krishnamoorthy, Rajagopal
PY - 2012/2
Y1 - 2012/2
N2 - This is the first study to evaluate the spectrum and prevalence of dose-predictive genetic polymorphisms of the CYP2C9, CYP4F2 and VKORC1 loci together, in a geographically defined, ethnically admixed healthy adult Omani population sharing common lifestyle/environmental factors. Since the present-day Omani population is the result of an admixture of Caucasian, African and Asian ancestries, we compared the pharmacogenetic profile of these three loci in this population. Interestingly, the Omani pharmacogenetic profile, in terms of allele and genotype distribution, has values that are intermediate between Caucasians and African Americans, the African admixture further substantiated by the presence of the CYP2C9*8 allele. However, limitations and usefulness of such comparisons warrant caution, as the data from pharmacogenetic literature do not always represent bona fide population categories. Furthermore, definition of study population based on microgeographical scale would be more appropriate in pharmacogenetic research rather than the flawed racial, ethnic, or social categorizations since pharmacogenetic variation is clinal, and genetic influences will be further altered by lifestyle and environmental factors.
AB - This is the first study to evaluate the spectrum and prevalence of dose-predictive genetic polymorphisms of the CYP2C9, CYP4F2 and VKORC1 loci together, in a geographically defined, ethnically admixed healthy adult Omani population sharing common lifestyle/environmental factors. Since the present-day Omani population is the result of an admixture of Caucasian, African and Asian ancestries, we compared the pharmacogenetic profile of these three loci in this population. Interestingly, the Omani pharmacogenetic profile, in terms of allele and genotype distribution, has values that are intermediate between Caucasians and African Americans, the African admixture further substantiated by the presence of the CYP2C9*8 allele. However, limitations and usefulness of such comparisons warrant caution, as the data from pharmacogenetic literature do not always represent bona fide population categories. Furthermore, definition of study population based on microgeographical scale would be more appropriate in pharmacogenetic research rather than the flawed racial, ethnic, or social categorizations since pharmacogenetic variation is clinal, and genetic influences will be further altered by lifestyle and environmental factors.
KW - CYP2C9
KW - CYP4F2
KW - Omani
KW - Pharmacogenetics
KW - VKORC1
KW - Warfarin
UR - http://www.scopus.com/inward/record.url?scp=84859519012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859519012&partnerID=8YFLogxK
U2 - 10.1353/hub.2012.0002
DO - 10.1353/hub.2012.0002
M3 - Article
C2 - 22452429
AN - SCOPUS:84859519012
SN - 0018-7143
VL - 84
SP - 67
EP - 77
JO - Human Biology
JF - Human Biology
IS - 1
ER -