TY - JOUR
T1 - Voltammetric determination of antibacterial drug gemifloxacin in solubilized systems at multi-walled carbon nanotubes modified glassy carbon electrode
AU - Jain Rajeev, R.
AU - Rather, Jahangir Ahmad
PY - 2011/4/1
Y1 - 2011/4/1
N2 - A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47-15.5 μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90. ng/mL and 3.0. ng/mL respectively.
AB - A sensitive electroanalytical method for determination of gemifloxacin in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at multi-walled carbon nanotubes modified glassy carbon electrode in the presence of CTAB. Solubilized system of different surfactants including SDS, Tween-20 and CTAB were taken for the study of electrochemical behaviour of gemifloxacin at modified electrode. The reduction peak current increases in the presence of CTAB while other surfactants show opposite effect. The modified electrode exhibits catalytic activity, high sensitivity, stability and is applicable over wide range of concentration for the determination of gemifloxacin. The mechanism of electrochemical reduction of gemifloxacin has been proposed on the basis of CV, SWV, DPV and coulometeric techniques. The proposed squarewave voltammetric method shows linearity over the concentration range 2.47-15.5 μg/mL. The achieved limits of detection (LOD) and quantification (LOQ) are 0.90. ng/mL and 3.0. ng/mL respectively.
KW - CTAB (cetyltrimethyl ammonium bromide)
KW - Gemifloxacin (GMX)
KW - Multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs-GCE)
KW - Solubilized systems
KW - Voltammetric determination
UR - http://www.scopus.com/inward/record.url?scp=78651420325&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78651420325&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2010.12.003
DO - 10.1016/j.colsurfb.2010.12.003
M3 - Article
C2 - 21177081
AN - SCOPUS:78651420325
SN - 0927-7765
VL - 83
SP - 340
EP - 346
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 2
ER -