Voltammetric behaviour of drotaverine hydrochloride in surfactant media and its enhancement determination in Tween-20

Rajeev Jain*, Vikas, Jahangir Ahmad Rather

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

24 اقتباسات (Scopus)

ملخص

Simple, sensitive and rapid adsorptive voltammetric behaviour of drotaverine hydrochloride onto the HMDE has been explored and validated in surfactant media by using cyclic, differential pulse and square-wave voltammetry. Addition of Tween-20 to the drotaverine hydrochloride containing electrolyte enhances the reduction current signal. The voltammograms of the drug with Tween-20 in phosphate buffers of pH 2.5-11.0 exhibit a single well defined reduction peak which may be due to the reduction of -CC- group. The cyclic voltammetric studies indicated the reduction of drotaverine hydrochloride at the electrode surface through two electron irreversible step and diffusion-controlled. The peak current showed a linear dependence with the drug concentration over the range 0.8-7.2μgmL-1. The calculated LOD and LOQ are 1.8 and 6.0ngmL-1 by SWCAdSV and 8.1 and 27.2ngmL-1 by DPCAdSV, respectively. The procedure was applied to the assay of the drug in tablet form with mean percentage recoveries of 100.2% with SWCAdSV and 99.7% with DPCAdSV. The validity of the proposed methods was further assessed by applying a standard addition technique.

اللغة الأصليةEnglish
الصفحات (من إلى)333-339
عدد الصفحات7
دوريةColloids and Surfaces B: Biointerfaces
مستوى الصوت82
رقم الإصدار2
المعرِّفات الرقمية للأشياء
حالة النشرPublished - فبراير 1 2011

ASJC Scopus subject areas

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  • ???subjectarea.asjc.3100.3110???
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