Visceral leishmaniasis and haemophagocytic syndrome in an Omani child

Khalfan Al Sineidi, Yasser A. Wali*, Anil V. Pathare, Zakia Al Lamki

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

3 اقتباسات (Scopus)

ملخص

The paper reports the case of a previously healthy 4-year-old-girl who presented with pallor, fever and hepatosplenomegaly. Laboratory findings included pancytopenia, hypertriglyceridemia and hyperferritinemia. Initial diagnosis of kala-azar could not be confirmed because of the absence of clinical evidence, negativity of bone marrow aspiration or specific serology for visceral leishmaniasis. Repeated marrow aspiration, performed due lack of clinical response, revealed histiocytes showing haemophagocytosis consistent with haemophagocytic lymphohistocytosis (HLH) and appropriate treatment was started. She continued to have high-grade fever, and a third bone marrow aspiration ultimately revealed presence of Leishmania amastigotes with evidence of active haemophagocytosis. The girl was treated with liposomal amphotericin (AmBisome) for 5 days, following which she recovered rapidly with definitive remission.

اللغة الأصليةEnglish
الصفحات (من إلى)45-48
عدد الصفحات4
دوريةSultan Qaboos University Medical Journal
مستوى الصوت4
رقم الإصدار1-2
حالة النشرPublished - أبريل 2002

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