Usutu virus growth in human cell lines: Induction of and sensitivity to type I and III interferons

Carolina Scagnolari*, Beniamino Caputo, Simona Trombetti, Giulia Cacciotti, Annalisa Soldà, Lucia Spano, Paolo Villari, Alessandra della Torre, Norbert Nowotny, Guido Antonelli

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

16 اقتباسات (Scopus)

ملخص

The mechanisms of Usutu virus (USUV) pathogenesis are largely unknown. The aim of this study was to evaluate the sensitivity of USUV to interferon (IFN) and the capacity of USUV to stimulate IFN production. Initial experiments were conducted to characterize the susceptibility of human cell lines to USUV infection and to evaluate the single-growth cycle replication curve of USUV. Results indicate that USUV is able to infect a variety of human cell lines, completing the replication cycle in Hep-2 and Vero cells within 48 h. Pre-treatment of cells with types I and III IFNs significantly inhibited the replication of USUV. However, the inhibitory effects of IFNs were considerably less if IFN was added after viral infection had been initiated. Also, USUV weakly induced types I and III IFNs.

اللغة الأصليةEnglish
الصفحات (من إلى)789-795
عدد الصفحات7
دوريةJournal of General Virology
مستوى الصوت94
رقم الإصدارPART4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أبريل 2013
منشور خارجيًانعم

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بصمة

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