Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes

Laïla Aïcha Hanafi, Marilène Bolduc, Marie Ève Laliberté Gagné, Florent Dufour, Yves Langelier, Mohammed Rachid Boulassel, Jean Pierre Routy, Denis Leclerc, Réjean Lapointe*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

21 اقتباسات (Scopus)

ملخص

Chimeric VLPs made of papaya mosaic virus (PapMV) trigger a CTL response through antigenic presentation of epitopes on MHC class I. Here, a chimeric VLP composed of malva mosaic virus (MaMV) was shown to share similar properties. We demonstrated the capacity of both VLPs to enter human APCs. The chimeric constructions were cross-presented in CD40-activated B lymphocytes leading to in vitro expansion of antigen-specific T lymphocytes. We showed that high concentrations of chimeric MaMV induced cell death, suggesting that some modifications can trigger collateral effects in vitro. Results suggest that potexvirus VLPs are an attractive vaccine platform for inducing a CTL response.

اللغة الأصليةEnglish
الصفحات (من إلى)5617-5626
عدد الصفحات10
دوريةVaccine
مستوى الصوت28
رقم الإصدار34
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2010
منشور خارجيًانعم

ASJC Scopus subject areas

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