Trisomy 21 as a Sole Acquired Abnormality in an Adult Omani Patient with CD7- and CD9-Positive Acute Myeloid Leukemia

Achandira M. Udayakumar*, Anil V. Pathare, S. Muralitharan, Asem A. Alghzaly, Salam Alkindi, J. A. Raeburn

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

8 اقتباسات (Scopus)

ملخص

We describe a case of acute myeloid leukemia (AML) in which trisomy 21 was the sole acquired cytogenetic abnormality. The immunophenotype showed positivity for CD7 and CD9 along with CD13, CD33, and CD34. The chromosomal analysis of bone marrow showed 47,XY +21 in all the metaphases analyzed. The constitutional karyotype was normal. The patient was an adult and did not have any features of Down's syndrome. The bone marrow morphology was AML-M2 as per the French-American-British (FAB) criteria. A final diagnosis of CD7- and CD9-positive AML-M2 was established with trisomy 21 as a sole cytogenetic abnormality. The patient responded remarkably well to chemotherapy and achieved complete clinical remission. This is the first case of CD7- and CD9-positive AML with trisomy 21 as a sole abnormality. A putative role for the co-expression of abnormal lymphoid markers in achieving quick remission is discussed.

اللغة الأصليةEnglish
الصفحات (من إلى)797-802
عدد الصفحات6
دوريةArchives of Medical Research
مستوى الصوت38
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أكتوبر 2007

ASJC Scopus subject areas

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