TY - JOUR
T1 - Treatment Of Breast Cancer; Review And Updates
AU - Furrukh, Muhammad
AU - Qureshi, Asim
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Cancer of the breast is the leading female cancer accounting for one fourth of the malignancies. The tumour remains the most researched, read and practiced upon around the Globe. The treatment has substantially improved breast cancer related outcomes, both for early as well as late stages with substantial improvements in disease free and overall survival. Therapeutic decisions not only rest on clinical & tumour characteristics, but also with the evolution of molecular biology and tissue microarray intrinsic sub-types have been found. Attempts are being made to translate therapy from genomic architecture of individual breast cancer. This facilitates customization of treatment avoiding un-necessary toxicity, costs and inconvenience. Optimizing treatment based on individual breast biology seems logical and allows unifying treatment. The paper reviews literature, incorporate updates and also describes immunohistochemistry based molecular classification: which are found simple to adapt, record, present and subsequently manage, summarizing clinical practices in management of these patients.
AB - Cancer of the breast is the leading female cancer accounting for one fourth of the malignancies. The tumour remains the most researched, read and practiced upon around the Globe. The treatment has substantially improved breast cancer related outcomes, both for early as well as late stages with substantial improvements in disease free and overall survival. Therapeutic decisions not only rest on clinical & tumour characteristics, but also with the evolution of molecular biology and tissue microarray intrinsic sub-types have been found. Attempts are being made to translate therapy from genomic architecture of individual breast cancer. This facilitates customization of treatment avoiding un-necessary toxicity, costs and inconvenience. Optimizing treatment based on individual breast biology seems logical and allows unifying treatment. The paper reviews literature, incorporate updates and also describes immunohistochemistry based molecular classification: which are found simple to adapt, record, present and subsequently manage, summarizing clinical practices in management of these patients.
KW - Antibodies, Monoclonal
KW - Breast
KW - Cancer; Molecular biology
KW - Immunohistochemistry
KW - Receptor, erb-B2;Therapy
KW - Triple negative
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M3 - Review article
C2 - 29938432
AN - SCOPUS:85054897722
SN - 1025-9589
VL - 30
SP - 264
EP - 274
JO - Journal of Ayub Medical College, Abbottabad : JAMC
JF - Journal of Ayub Medical College, Abbottabad : JAMC
IS - 2
ER -