TY - JOUR
T1 - The steroidal glycoalkaloids solamargine and solasonine in Solanum plants
AU - Al Sinani, S. S.S.
AU - Eltayeb, E. A.
N1 - Publisher Copyright:
© 2017 SAAB
PY - 2017/9
Y1 - 2017/9
N2 - Glycoalkaloids are a class of nitrogen-containing steroidal glycosides, they are biologically active secondary metabolites and are commonly found in plants of the genus Solanum. These compounds have been the subject of many literature papers, they occur widely in the human diet including potato (Solanum tuberosum), tomato (Solanum lycopersicum) and aubergine (Solanum melongena) and are known to induce toxicity. Therefore, from the food safety and biological activity perspectives further information is required regarding their analysis, toxicity and bioavailability. A comprehensive review of different analytical methods of quantification of two glycoalkaloids solamargine and solasonine and their bioactivity particularly focused on toxicity, anticancer activity and mechanisms of action is presented in this paper.
AB - Glycoalkaloids are a class of nitrogen-containing steroidal glycosides, they are biologically active secondary metabolites and are commonly found in plants of the genus Solanum. These compounds have been the subject of many literature papers, they occur widely in the human diet including potato (Solanum tuberosum), tomato (Solanum lycopersicum) and aubergine (Solanum melongena) and are known to induce toxicity. Therefore, from the food safety and biological activity perspectives further information is required regarding their analysis, toxicity and bioavailability. A comprehensive review of different analytical methods of quantification of two glycoalkaloids solamargine and solasonine and their bioactivity particularly focused on toxicity, anticancer activity and mechanisms of action is presented in this paper.
KW - Anticancer
KW - Secondary metabolites
KW - Solamargine
KW - Solanaceae
KW - Solasonine
KW - Steroidal glycoalkaloids
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U2 - 10.1016/j.sajb.2017.06.002
DO - 10.1016/j.sajb.2017.06.002
M3 - Review article
AN - SCOPUS:85034107017
SN - 0254-6299
VL - 112
SP - 253
EP - 269
JO - South African Journal of Botany
JF - South African Journal of Botany
ER -