TY - JOUR
T1 - The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia
AU - Sulaiman, Ahmad Hatim
AU - Said, Mas Ayu
AU - Habil, Mohd Hussain
AU - Rashid, Rusdi
AU - Siddiq, Amer
AU - Guan, Ng Chong
AU - Midin, Marhani
AU - Jaafar, Nik Ruzyanei Nik
AU - Sidi, Hatta
AU - Das, Srijit
N1 - Funding Information:
Publication of this supplement was supported by Universiti Kebangsaan Malaysian Medical Centre, Kuala Lumpur, Malaysia.
Funding Information:
Source of funding: University of Malaya Research Grant .
PY - 2014/1
Y1 - 2014/1
N2 - Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.
AB - Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.
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U2 - 10.1016/j.comppsych.2013.01.003
DO - 10.1016/j.comppsych.2013.01.003
M3 - Article
C2 - 23433219
AN - SCOPUS:84889882131
SN - 0010-440X
VL - 55
SP - S89-S94
JO - Comprehensive Psychiatry
JF - Comprehensive Psychiatry
IS - SUPPL. 1
ER -