ملخص
1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, the drug reduced significantly the erythrocyte counts, haemoglobin concentration, haematocrit, mean corpuscular haemoglobin concentration and mean corpuscular haemoglobin on weeks 1, 2, 3 and 4. Platelet counts were not significantly affected. 2. In another trial, ivermectin was injected subcutaneously at a dose of 2.5 mg/kg, after pre‐treatment with either saline or vitamin K (30 μg/kg for 30 days), and prothrombin time, bleeding time and platelet counts measured at weekly intervals for 4 weeks. Bleeding time and thrombin time were significantly increased 1 week after treatment, and remained higher than the control for 4 weeks.
اللغة الأصلية | English |
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الصفحات (من إلى) | 735-738 |
عدد الصفحات | 4 |
دورية | Clinical and Experimental Pharmacology and Physiology |
مستوى الصوت | 17 |
رقم الإصدار | 10 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - أكتوبر 1990 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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- ???subjectarea.asjc.2700.2737???