TY - JOUR
T1 - The Dual Pandemics of COVID-19 and Obesity
T2 - Bidirectional Impact
AU - The CArdiometabolic Panel of International experts on Syndemic COvid-19 (CAPISCO)
AU - Kapoor, Nitin
AU - Kalra, Sanjay
AU - Al Mahmeed, Wael
AU - Al-Rasadi, Khalid
AU - Al-Alawi, Kamila
AU - Banach, Maciej
AU - Banerjee, Yajnavalka
AU - Ceriello, Antonio
AU - Cesur, Mustafa
AU - Cosentino, Francesco
AU - Firenze, Alberto
AU - Galia, Massimo
AU - Goh, Su Yen
AU - Janez, Andrej
AU - Kempler, Peter
AU - Lessan, Nader
AU - Lotufo, Paulo
AU - Papanas, Nikolaos
AU - Rizvi, Ali A.
AU - Sahebkar, Amirhossein
AU - Santos, Raul D.
AU - Stoian, Anca Pantea
AU - Toth, Peter P.
AU - Viswanathan, Vijay
AU - Rizzo, Manfredi
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/10
Y1 - 2022/10
N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.
AB - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurrence of COVID-19 but can also result in a worse clinical outcome of COVID-19 infection. This manuscript summarizes the most recent evidence supporting the bidirectional impact of COVID-19 and obesity. It highlights how the presence of obesity can be detrimental to the outcome of COVID-19 in a given patient because of the mechanical limitations in lung compliance and also by the activation of several thrombo-inflammatory pathways. The sociodemographic changes brought about by the pandemic in turn have facilitated the already increasing prevalence of obesity. This manuscript highlights the importance of recognizing these pathways which may further help in policy changes that facilitate appropriate measures to prevent the further worsening of these two pandemics.
KW - Bidirectional impact
KW - COVID-19
KW - Obesity
KW - SARS-CoV-2
KW - Syndemic
UR - http://www.scopus.com/inward/record.url?scp=85137114881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137114881&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6b1ded18-8f91-3724-8fec-c4a764cbbd49/
U2 - 10.1007/s13300-022-01311-2
DO - 10.1007/s13300-022-01311-2
M3 - Review article
C2 - 36030317
AN - SCOPUS:85137114881
SN - 1869-6953
VL - 13
SP - 1723
EP - 1736
JO - Diabetes Therapy
JF - Diabetes Therapy
IS - 10
ER -