TY - JOUR
T1 - Synthesis, conformation, and antiviral activity of 5-methoxymethyl-2′-deoxycytidine analogs
AU - Zoghaib, Wajdi M.
AU - Mannala, Shajan
AU - Gupta, V. Sagar
AU - Tourigny, Guy
AU - Reid, R. Stephen
N1 - Funding Information:
This research was funded by grants from the Medical Research Council of Canada to Dr. V. S. Gupta, grant: MA 10254. The authors wish to thank the College of Graduate Studies and Research, University of Saskatchewan, for scholarship support to Mr. Wajdi Michel Zoghaib and Mr. Shajan Mannala, and the Department of Chemistry, University of Saskatchewan, for providing funds for consumables. The authors also wish to thank Dr. Sashi Kumar and Dr. Allan Stuart for their constructive advice and helpful discussions.
PY - 2003
Y1 - 2003
N2 - Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
AB - Analogs of 5-methoxymethyl-2′-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
KW - 5-methoxymethyl-2′-deoxycytidine
KW - Conformation
KW - Herpes Simplex Virus
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U2 - 10.1081/NCN-120019532
DO - 10.1081/NCN-120019532
M3 - Article
C2 - 12744607
AN - SCOPUS:0037264166
SN - 1525-7770
VL - 22
SP - 223
EP - 238
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 2
ER -