ملخص
A new series of 4-(4′-chlorophenyl)-4-hydroxypiperidine derivatives (2-5), substituted at nitrogen, were synthesized and tested as potential analgesic compounds as well as evaluated for their effect on hypotensive activity. Results showed that all the derivatives exhibit significant analgesic activity in male Wistar rats at a dose of 50 mg/kg of body weight after intramuscular injection, when tested by thermal stimuli (tail flick test). Pethidine was used as reference drug. Compounds 2, 3 and 5 produced reduction in blood pressure in normotensive rat.
اللغة الأصلية | English |
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الصفحات (من إلى) | 64-66 |
عدد الصفحات | 3 |
دورية | Chemical and Pharmaceutical Bulletin |
مستوى الصوت | 53 |
رقم الإصدار | 1 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - يناير 2005 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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- ???subjectarea.asjc.3000.3002???