TY - JOUR
T1 - Supercritical fluids and their applications in biotechnology and related areas
AU - Williams, John R.
AU - Clifford, Anthony A.
AU - Al-Saidi, Salim H.R.
PY - 2002/11
Y1 - 2002/11
N2 - This article serves as an overview, introducing the currently popular area of supercritical fluids (SFs) and their uses in biotechnology and related areas. It covers the fundamentals of supercritical science and moves on to the biotechnological and associated applications of these fluids. Subject areas covered include pure substances as supercritical fluids, the properties of supercritical fluids, organic cosolvents, solubility, and the following applications: extraction, chromatography, reactions, particle production, deposition, and the drying of biological specimens. Within each application, and where possible, the basic principles of the technique are given, as well as a description of the history, instrumentation, methodology, uses, problems encountered, and advantages over the traditional, nonsupercritical methods.
AB - This article serves as an overview, introducing the currently popular area of supercritical fluids (SFs) and their uses in biotechnology and related areas. It covers the fundamentals of supercritical science and moves on to the biotechnological and associated applications of these fluids. Subject areas covered include pure substances as supercritical fluids, the properties of supercritical fluids, organic cosolvents, solubility, and the following applications: extraction, chromatography, reactions, particle production, deposition, and the drying of biological specimens. Within each application, and where possible, the basic principles of the technique are given, as well as a description of the history, instrumentation, methodology, uses, problems encountered, and advantages over the traditional, nonsupercritical methods.
KW - Particles from gas-saturated solution
KW - Rapid expansion of supercritical solutions
KW - Solution enhanced dispersion by supercritical fluids
KW - Supercritical antisolvent
KW - Supercritical fluid chromatography
KW - Supercritical fluid extraction
KW - Supercritical fluids
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U2 - 10.1385/MB:22:3:263
DO - 10.1385/MB:22:3:263
M3 - Review article
C2 - 12448881
AN - SCOPUS:0036830362
SN - 1073-6085
VL - 22
SP - 263
EP - 286
JO - Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology
JF - Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology
IS - 3
ER -