ملخص
2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)benzimidazoles (8a-k) were synthesized for bioassay via interaction of 4-fluoro-5-(4-methyl-1-piperazinyl)-1,2-diaminobenzene (6) with the appropriate aldehyde. The intermediate Schiff bases (7a-k) were isolated and converted, thermally in nitrobenzene, to the respective heterocycles (8a-k). However, none of the tested model compounds (8c-e) showed any significant in vitro activity against Pseudomonas aeruginosa, Staphylococcus aureus, Aspergillus parasiticus and Candida albicans at concentration ≤ 100 μg/ml.
اللغة الأصلية | English |
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الصفحات (من إلى) | 2713-2728 |
عدد الصفحات | 16 |
دورية | Heterocycles |
مستوى الصوت | 41 |
رقم الإصدار | 12 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - ديسمبر 1 1995 |
منشور خارجيًا | نعم |
ASJC Scopus subject areas
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