TY - JOUR
T1 - Stripping voltammetric detection of nephrotoxic drug cefitizoxime in wastewater
AU - Rather, Jahangir Ahmad
AU - Jain, Rajeev
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The objective of the present work is to develop the stripping voltammetric method for determination of nephrotoxic drug cefitizoxime in pharmaceutical formulation and its application to wastewater analysis. Solubilized system of different surfactants viz. cationic, anionic and non-ionic influences the electrochemical response of cefitizoxime. Solubilized system of CTAB containing cefitizoxime enhanced the peak current while anionic and non-ionic showed an opposite effect. The current signal due to the reduction process is a function of concentration of the cefitizoxime, pH of medium, type of surfactant and accumulation time at electrode surface. The proposed SWCAdSV (Squarewave Cathodic Adsorptive Voltammtery) and DPCAdSV (Differential Pulse Cathodic Adsorptive Voltammetry) are linear over concentration range 1.732-6.901 μg/mL and 4.792-30.672 μg/mL with detection limit of 0.76 ng/mL and 2.63 ng/mL, respectively. The method is successfully applied for determination of cefitizoxime in pharmaceutical formulation and wastewater with mean percentage recovery of 99.73% and 98.51%, respectively.
AB - The objective of the present work is to develop the stripping voltammetric method for determination of nephrotoxic drug cefitizoxime in pharmaceutical formulation and its application to wastewater analysis. Solubilized system of different surfactants viz. cationic, anionic and non-ionic influences the electrochemical response of cefitizoxime. Solubilized system of CTAB containing cefitizoxime enhanced the peak current while anionic and non-ionic showed an opposite effect. The current signal due to the reduction process is a function of concentration of the cefitizoxime, pH of medium, type of surfactant and accumulation time at electrode surface. The proposed SWCAdSV (Squarewave Cathodic Adsorptive Voltammtery) and DPCAdSV (Differential Pulse Cathodic Adsorptive Voltammetry) are linear over concentration range 1.732-6.901 μg/mL and 4.792-30.672 μg/mL with detection limit of 0.76 ng/mL and 2.63 ng/mL, respectively. The method is successfully applied for determination of cefitizoxime in pharmaceutical formulation and wastewater with mean percentage recovery of 99.73% and 98.51%, respectively.
KW - Cefitizoxime (Ceftz.)
KW - Pharmaceutical formulation
KW - Solubilized system
KW - Stripping voltammetric techniques
KW - Wastewater
UR - http://www.scopus.com/inward/record.url?scp=84926287050&partnerID=8YFLogxK
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U2 - 10.1016/j.ancr.2015.03.002
DO - 10.1016/j.ancr.2015.03.002
M3 - Article
AN - SCOPUS:84926287050
SN - 2214-1812
VL - 4
SP - 13
EP - 19
JO - Analytical Chemistry Research
JF - Analytical Chemistry Research
ER -