Signaling pathways of hyperhomocystenemia and oxidative stress

Mostafa I. Waly*

*المؤلف المقابل لهذا العمل

نتاج البحث: Chapter


Homocysteine (HCY) is a non-protein-forming, sulfur amino acid whose metabolism is at the intersection of two metabolic pathways, remethylation and trans-sulfuration pathways. HCY is characterized by its chemical tendency to promote oxidative stress and cellular toxicity. Three major forms of homocysteine species exist in human blood circulation; albumin-bound, disulfide from, and sulfhydryl form. Current laboratory methods detect the presence of all three forms and report this as total homocysteine concentration [1]. Normal homocysteine concentrations range from 5-15 μmol/L, intermediately elevated homocysteine levels are between 31 and 100 μmol/L, while severely elevated levels are >100 μmol/L [1].

اللغة الأصليةEnglish
عنوان منشور المضيفNutritional Management and Metabolic Aspects of Hyperhomocysteinemia
ناشرSpringer International Publishing
عدد الصفحات7
رقم المعيار الدولي للكتب (الإلكتروني)9783030578398
رقم المعيار الدولي للكتب (المطبوع)9783030578381
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 2 2021

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