SEX DIFFERENCES AND THE EFFECT OF GONADECTOMY ON MORPHINE‐INDUCED ANTINOCICEPTION AND DEPENDENCE IN RATS AND MICE

B. H. Ali*, S. I. Sharif, A. Elkadi

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

75 اقتباسات (Scopus)

ملخص

1. Differences between sexes and the effect of bilateral surgical gonadectomy on the response to morphine analgesia and dependence were examined in rats and mice. 2. The analgesic response to morphine (5 mg/kg) was assessed by the hot plate and the abdominal constriction tests. Dependence was induced by injecting morphine at increasing doses (5–160 mg/kg) for 6 consecutive days and withdrawal signs elicited by injecting naloxone (2.5 mg/kg). 3. The base line reaction times in the intact control, shamoperated and gonadectomized animals of either sex were not significantly different from each other. 4. After treatment with morphine, the percentage increase in the reaction time in gonadectomized male and female rats and in gonadectomized male mice was significantly higher than in their respective controls. 5. The increase in the reaction time, after morphine treatment, was significantly higher in gonadectomized female rats than in gonadectomized male rats. 6. Naloxone‐induced withdrawal signs in morphine‐dependent gonadectomized rats and mice were not significantly different from those in sham‐operated controls. However, female rats in both groups exhibited a significantly higher number of escape jumping responses than males.

اللغة الأصليةEnglish
الصفحات (من إلى)342-344
عدد الصفحات3
دوريةClinical and Experimental Pharmacology and Physiology
مستوى الصوت22
رقم الإصدار5
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 1995
منشور خارجيًانعم

ASJC Scopus subject areas

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بصمة

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