TY - JOUR
T1 - Serum resistance of Escherichia coli strains causing urinary tract inifection and diarrhoea in relation to alpha haemolysin production and O type
AU - Rizvi, Meher
AU - Kumar, Surinder
PY - 2003/7
Y1 - 2003/7
N2 - A total of 46 α-hemolytic and 40 non-hemolytic clinical isolates of Escherichia coli were collected from pediatric patients with urinary tract infection and diarrhoea. Of 39 (84.7%) α-hemolytic strains and 27(67.5%) non-hemolytic strains were resistant to 10% serum and there was no significant difference between urinary and stool isolates. On the contrary when 100% serum was used, 22(47.8%) of the a-hemolytic and 7(17.5%) of the non-hemolytic strains were resistant (p<0.01). and significantly greater resistance was found in urinary tract infection than from the stool samples (47% versus 24%, p<0.01). Serum resistance was higher in serogroups O6, O18 and O75. Production of α-hemolysin was more frequent in serogrops O2, O6, O8, O18 and O75. Thus, the resistance to human serum can determine clinical significance of Escherichia colifrom different sources and α-hemolysin contributes to the virulence of Escherichia coli in initiation and perpetuation of clinical infection.
AB - A total of 46 α-hemolytic and 40 non-hemolytic clinical isolates of Escherichia coli were collected from pediatric patients with urinary tract infection and diarrhoea. Of 39 (84.7%) α-hemolytic strains and 27(67.5%) non-hemolytic strains were resistant to 10% serum and there was no significant difference between urinary and stool isolates. On the contrary when 100% serum was used, 22(47.8%) of the a-hemolytic and 7(17.5%) of the non-hemolytic strains were resistant (p<0.01). and significantly greater resistance was found in urinary tract infection than from the stool samples (47% versus 24%, p<0.01). Serum resistance was higher in serogroups O6, O18 and O75. Production of α-hemolysin was more frequent in serogrops O2, O6, O8, O18 and O75. Thus, the resistance to human serum can determine clinical significance of Escherichia colifrom different sources and α-hemolysin contributes to the virulence of Escherichia coli in initiation and perpetuation of clinical infection.
KW - O serogroups
KW - Serum resistance
KW - α-haemolysin
UR - http://www.scopus.com/inward/record.url?scp=1142286656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1142286656&partnerID=8YFLogxK
M3 - Article
C2 - 15025325
AN - SCOPUS:1142286656
SN - 0377-4929
VL - 46
SP - 504
EP - 506
JO - Indian Journal of Pathology and Microbiology
JF - Indian Journal of Pathology and Microbiology
IS - 3
ER -