TY - JOUR
T1 - Role of adrenal imaging in surgical management
AU - Lamki, Lamk M.
AU - Haynie, Thomas P.
PY - 1990/3
Y1 - 1990/3
N2 - Adrenal imaging using radiopharmaceuticals is a functional test that can contribute significantly to surgical management and follow‐up of patients with either benign or malignant conditions of the adrenal cortex and medulla. Imaging of the cortex is achieved by iodine‐131‐labeled iodomethyl nor‐cholesterol (NP‐59), while adrenal medulla imaging can be successfully accomplished by 131I‐metaiodobenzylguanidine (MIBG), which localizes in the adrenergic nerve terminal with norepinephrine. Both tests carry high sensitivity and specificity for functional tumors and hyperplasia, and often better than CT scanning. This article reviews the current status and clinical utility of nuclear imaging of the adrenal cortex in congenital hyperplasia, low renin hypertension and aldosteronism, and Cushing's syndrome. Adrenal medulla imaging is reviewed in light of our experience at the University of Texas M.D. Anderson Cancer Center in pheochromocytoma, neuroblastoma, and other neuroectodermal tumors. Investigation of 131I‐MIBG therapy of metastatic tumors of neuroectodermal origin potentially offers a means of at least controlling symptoms of hormonal secretion in these patients.
AB - Adrenal imaging using radiopharmaceuticals is a functional test that can contribute significantly to surgical management and follow‐up of patients with either benign or malignant conditions of the adrenal cortex and medulla. Imaging of the cortex is achieved by iodine‐131‐labeled iodomethyl nor‐cholesterol (NP‐59), while adrenal medulla imaging can be successfully accomplished by 131I‐metaiodobenzylguanidine (MIBG), which localizes in the adrenergic nerve terminal with norepinephrine. Both tests carry high sensitivity and specificity for functional tumors and hyperplasia, and often better than CT scanning. This article reviews the current status and clinical utility of nuclear imaging of the adrenal cortex in congenital hyperplasia, low renin hypertension and aldosteronism, and Cushing's syndrome. Adrenal medulla imaging is reviewed in light of our experience at the University of Texas M.D. Anderson Cancer Center in pheochromocytoma, neuroblastoma, and other neuroectodermal tumors. Investigation of 131I‐MIBG therapy of metastatic tumors of neuroectodermal origin potentially offers a means of at least controlling symptoms of hormonal secretion in these patients.
KW - adrenal cortex imaging
KW - adrenal medulla imaging
KW - adrenal scintigraphy
KW - iodocholesterol scan (NP‐59)
KW - meta‐iodobenzylguanidine (MIBG)
KW - nuclear scintiscan—adrenal
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U2 - 10.1002/jso.2930430304
DO - 10.1002/jso.2930430304
M3 - Article
C2 - 2179629
AN - SCOPUS:0025213180
SN - 0022-4790
VL - 43
SP - 139
EP - 147
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 3
ER -