Review: Management of painful vaso-occlusive crisis of sickle-cell anemia: Consensus opinion

Shaker A. Mousa, Abbdulkareem Al Momen, Faisal Al Sayegh, Soad Al Jaouni, Zaki Nasrullah, Hussein Al Saeed, Abbas Alabdullatif, Mohamad Al Sayegh, Hazaa Al Zahrani, Maha Hegazi, Amin Al Mohamadi, A. Alsulaiman, Awad Omer, Salam Al Kindi, Ahamd Tarawa, Fahad Al Othman, Mohammad Qari

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء

28 اقتباسات (Scopus)

ملخص

Sickle-cell disease (SCD) is a wide-spread inherited hemolytic anemia that is due to a point mutation, leading to the substitution of valine for glutamic acid, causing a spectrum of clinical manifestations in addition to hemolysis and anemia. Acute painful crisis is a common sequela that can cause significant morbidity and negatively impact the patients quality of life. Remarkable improvements in the understanding of the pathogenesis of this clinical syndrome and the role of cell adhesion, inflammation, and coagulation in acute painful crisis have led to changes in the management of pain. Due to the endemic nature of SCD in various parts of the Middle East, a group of physicians and scientists from the United States and Middle East recently met to draw up a set of suggested guidelines for the management of acute painful crisis that are reflective of local and international experience. This review brings together a detailed etiology, the pathophysiology, and clinical presentation of SCD, including the differential diagnoses of pain associated with the disease, with evidence-based recommendations for pain management and the potential impact of low-molecular-weight heparin (LMWH), from the perspective of physicians and scientists with long-term experience in the management of a large number of patients with SCD.

اللغة الأصليةEnglish
الصفحات (من إلى)365-376
عدد الصفحات12
دوريةClinical and Applied Thrombosis/Hemostasis
مستوى الصوت16
رقم الإصدار4
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2010

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