TY - JOUR
T1 - Regional consensus opinion for the management of Beta thalassemia major in the Arabian Gulf area
AU - Qari, Mohamad H.
AU - Wali, Yasser
AU - Albagshi, Muneer H.
AU - Alshahrani, Mohammad
AU - Alzahrani, Azzah
AU - Alhijji, Ibrahim A.
AU - Almomen, Abdulkareem
AU - Aljefri, Abdullah
AU - Al Saeed, Hussain H.
AU - Abdullah, Shaker
AU - Al Rustumani, Ahmad
AU - Mahour, Khoutir
AU - Mousa, Shaker A.
N1 - Funding Information:
This work was funded in part through an unrestricted grant from ApoPharma Inc., Toronto, Canada. Kelly A. Keating (Albany College of Pharmacy and Health Sciences) edited the manuscript for English language and organization.
PY - 2013
Y1 - 2013
N2 - Thalassemia syndrome has diverse clinical presentations and a global spread that has far exceeded the classical Mediterranean basin where the mutations arose. The mutations that give rise to either alpha or beta thalassemia are numerous, resulting in a wide spectrum of clinical severity ranging from carrier state to life-threatening, inherited hemolytic anemia that requires regular blood transfusion. Beta thalassemia major constitutes a remarkable challenge to health care providers. The complications arising due to the anemia, transfusional iron overload, as well as other therapy-related complications add to the complexity of this condition. To produce this consensus opinion manuscript, a PubMed search was performed to gather evidence-based original articles, review articles, as well as published work reflecting the experience of physicians and scientists in the Arabian Gulf region in an effort to standardize the management protocol.
AB - Thalassemia syndrome has diverse clinical presentations and a global spread that has far exceeded the classical Mediterranean basin where the mutations arose. The mutations that give rise to either alpha or beta thalassemia are numerous, resulting in a wide spectrum of clinical severity ranging from carrier state to life-threatening, inherited hemolytic anemia that requires regular blood transfusion. Beta thalassemia major constitutes a remarkable challenge to health care providers. The complications arising due to the anemia, transfusional iron overload, as well as other therapy-related complications add to the complexity of this condition. To produce this consensus opinion manuscript, a PubMed search was performed to gather evidence-based original articles, review articles, as well as published work reflecting the experience of physicians and scientists in the Arabian Gulf region in an effort to standardize the management protocol.
KW - Anemia
KW - Arabian Gulf
KW - Chelation
KW - Iron chelation therapy
KW - Iron overload
KW - Thalassemia management
KW - Transfusion
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U2 - 10.1186/1750-1172-8-143
DO - 10.1186/1750-1172-8-143
M3 - Review article
C2 - 24044606
AN - SCOPUS:84883850016
SN - 1750-1172
VL - 8
JO - Orphanet Journal of Rare Diseases
JF - Orphanet Journal of Rare Diseases
IS - 1
M1 - 143
ER -