Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells

Mostafa I. Waly*, Badreldin H. Ali, Intisar Al-Lawati, Abderrahim Nemmar

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

42 اقتباسات (Scopus)

ملخص

Emodin (a rhubarb anthraquinone) has strong antioxidant and anticancer actions, and recent studies indicated that it reduces cellular oxidative stress induced by various insults and drugs. Cisplatin is an anticancer drug that is associated with nephrotoxicity and induces oxidative stress in cultured human kidney (HEK 293) cells. This study aimed to assess the in-vitro antioxidant properties of the emodin against cisplatin-induced oxidative stress in HEK 293 cells. Our study revealed that emodin acted as a potent free radical scavenger and provided nephroprotection against cisplatin-induced oxidative stress. Emodin as low as 0.5μm did not decrease cell viability and restored the cisplatin-induced glutathione depletion and total antioxidant capacity in a dose-dependent manner. Emodin augmented the cisplatin-induced inhibition of antioxidant enzymes (catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase and superoxide dismutase). These results suggest that emodin has the potential to be used as an adjunct therapeutic agent in patients receiving cisplatin treatment.

اللغة الأصليةEnglish
الصفحات (من إلى)626-630
عدد الصفحات5
دوريةJournal of Applied Toxicology
مستوى الصوت33
رقم الإصدار7
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يوليو 2013

ASJC Scopus subject areas

  • ???subjectarea.asjc.3000.3005???

بصمة

أدرس بدقة موضوعات البحث “Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells'. فهما يشكلان معًا بصمة فريدة.

قم بذكر هذا