TY - JOUR
T1 - Profiling cell-free and circulating miRNA
T2 - a clinical diagnostic tool for different cancers
AU - Chakraborty, Chiranjib
AU - Das, Srijit
N1 - Publisher Copyright:
© 2016, International Society of Oncology and BioMarkers (ISOBM).
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Effective cancer management depends on early diagnosis and treatment. There are several microRNAs (miRNAs) which are used for detection of various cancers. Cell-free and circulating miRNAs originate from plasma, either from blood cells or endothelial cells. Cell-free and circulating miRNAs are very much important in the diagnosis and prognosis of cancer therapy. Admittedly, biological knowledge of extracellular miRNAs is still at its preliminary level. Recent discoveries of novel cell-free and circulating miRNAs from the body fluids are now being considered as important biomarkers that may help us in the early diagnosis of any cancer. In the present review, we highlight the biogenesis of miRNAs and their current extracellular pattern, the discovery of circulating miRNA, significant advantages, and different profiling techniques. Finally, we discuss the different circulating miRNAs such as miR-21, miR-20a, miR-155, miR‑221, miR-210, miR-218, miR-200-family, miR-141, miR-122, miR-486-5p, miR‑423-5p, miR-29a, and miR-500 for clinical diagnosis of various cancers. The present review may be beneficial for future researches concerned with miRNAs which are used for detection of various cancers.
AB - Effective cancer management depends on early diagnosis and treatment. There are several microRNAs (miRNAs) which are used for detection of various cancers. Cell-free and circulating miRNAs originate from plasma, either from blood cells or endothelial cells. Cell-free and circulating miRNAs are very much important in the diagnosis and prognosis of cancer therapy. Admittedly, biological knowledge of extracellular miRNAs is still at its preliminary level. Recent discoveries of novel cell-free and circulating miRNAs from the body fluids are now being considered as important biomarkers that may help us in the early diagnosis of any cancer. In the present review, we highlight the biogenesis of miRNAs and their current extracellular pattern, the discovery of circulating miRNA, significant advantages, and different profiling techniques. Finally, we discuss the different circulating miRNAs such as miR-21, miR-20a, miR-155, miR‑221, miR-210, miR-218, miR-200-family, miR-141, miR-122, miR-486-5p, miR‑423-5p, miR-29a, and miR-500 for clinical diagnosis of various cancers. The present review may be beneficial for future researches concerned with miRNAs which are used for detection of various cancers.
KW - Biomarkers
KW - Cancer
KW - Diagnosis
KW - miRNA
UR - http://www.scopus.com/inward/record.url?scp=84971219408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971219408&partnerID=8YFLogxK
U2 - 10.1007/s13277-016-4907-3
DO - 10.1007/s13277-016-4907-3
M3 - Review article
C2 - 26831657
AN - SCOPUS:84971219408
SN - 1010-4283
VL - 37
SP - 5705
EP - 5714
JO - Tumor Biology
JF - Tumor Biology
IS - 5
ER -