Production of phenylacetic acid derivatives and 4-epiradicinol in culture by Curvularia lunata

Gouri B. Varma, Majekodunmi O. Fatope*, Ruchi G. Marwah, Mike E. Deadman, Fathiya K. Al-Rawahi

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

21 اقتباسات (Scopus)

ملخص

Phenylacetic acid derivatives, methyl 2-acetyl-3,5-dihydroxyphenylacetate (1) and methyl 2-acetyl-5-hydroxy-3-methoxyphenylacetate (3); curvulin or ethyl 2-acetyl-3,5-dihydroxyphenylacetate (4), a known metabolite of Curvularia siddiqui, and 4-epiradicinol (5) have been isolated from the culture mycelia of Curvularia lunata grown on YMG, a medium consisting of yeast, malt extract and glucose. Compounds 1, 3 and 4 lack antimicrobial and antioxidant activity, but 4-epiradicinol (5) inhibited the growth of Escherichia coli, Staphylococcus aureus, Salmonella choleraesuis and Bacillus subtilis. The structures of compounds 1, 3-5 were determined by analyses of IR, MS, 1D and 2D NMR data, assisted by chemical shift comparison to related and model compounds. The relative stereochemistry of the vicinal diol in 5 was determined from the 1H NMR signals for the methyl protons of the resulting cyclic acetonide prepared from 5.

اللغة الأصليةEnglish
الصفحات (من إلى)1925-1930
عدد الصفحات6
دوريةPhytochemistry
مستوى الصوت67
رقم الإصدار17
المعرِّفات الرقمية للأشياء
حالة النشرPublished - سبتمبر 2006

ASJC Scopus subject areas

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