Production of efrapeptins by Tolypocladium species and evaluation of their insecticidal and antimicrobial properties

A. R. Bandani*, B. P.S. Khambay, J. L. Faull, R. Newton, M. Deadman, T. M. Butt

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

55 اقتباسات (Scopus)

ملخص

This study shows for the first time that Tolypocladium species produce efrapeptins, a group of toxic peptides, in vivo but the quantities are too small to account for insect death, suggesting that these insecticidal compounds work in concert with other pathogenicity determinants. There is inter- and intraspecific variation in efrapeptin production in vitro by Tolypocladium species. T. parasiticum produced only efrapeptin E, in small quantities. Efrapeptins were detectable 48 h after inoculation and increased with biomass. The relative amounts of individual efrapeptins (C, D, E, F, G) produced by T. niveum in vitro were D > E > F > C > G but in vivo they were D > F > C > E > G. Efrapeptins were toxic to a wide range of insects when injected into the haemocoel. Mortality was dose-related. Efrapeptins also exhibited limited antifungal and antibacterial activity. Micrococcus luteus was considered an excellent indicator of efrapeptin presence in culture filtrate extracts because of its extreme sensitivity to these compounds.

اللغة الأصليةEnglish
الصفحات (من إلى)537-544
عدد الصفحات8
دوريةMycological Research
مستوى الصوت104
رقم الإصدار5
المعرِّفات الرقمية للأشياء
حالة النشرPublished - مايو 2000
منشور خارجيًانعم

ASJC Scopus subject areas

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