TY - JOUR
T1 - Prevalence of neutralizing antibodies to Equine rhinitis A and B virus in horses and man
AU - Kriegshäuser, G.
AU - Deutz, A.
AU - Kuechler, E.
AU - Skern, T.
AU - Lussy, H.
AU - Nowotny, N.
N1 - Funding Information:
This work was supported by grants from the Austrian Science Foundation to G.K. (WK-01) and from the Austrian National Bank (Jubiläumsfonds Nr. 7140) to E.K. We thank M. Weiss (University of Berne, Switzerland) for ERAV and ERBV1 as well as reference antisera.
PY - 2005/4/10
Y1 - 2005/4/10
N2 - Equine rhinitis viruses (ERVs) are the causative agents of mild to severe upper respiratory infections in horses worldwide. Immunologically, four serotypes of ERVs have been identified. Equine rhinitis A virus (ERAV) and Equine rhinitis B virus 1 (ERBV1) are the most frequent serotypes in Europe. Both viruses have a broad host range in cultured cells with ERAV being able to infect humans. Since there is neither information on the seroprevalence of ERAV and ERBV1 in Austria nor on the zoonotic potential of ERBV1, we investigated 200 horse and 137 veterinary sera for the presence of neutralizing antibodies relating to ERAV and ERBV1. One hundred and eighty (90%) and 173 (86%) horse sera neutralized ERAV and ERBV1, respectively. In contrast, only four (2.7%) and five (3.6%) human sera showed weak neutralizing activity to ERAV and ERBV1, respectively. These results indicate that ERAV and ERBV1 are widespread in the Austrian horse population; however, the risk of acquiring zoonotic infection among veterinarians appears low.
AB - Equine rhinitis viruses (ERVs) are the causative agents of mild to severe upper respiratory infections in horses worldwide. Immunologically, four serotypes of ERVs have been identified. Equine rhinitis A virus (ERAV) and Equine rhinitis B virus 1 (ERBV1) are the most frequent serotypes in Europe. Both viruses have a broad host range in cultured cells with ERAV being able to infect humans. Since there is neither information on the seroprevalence of ERAV and ERBV1 in Austria nor on the zoonotic potential of ERBV1, we investigated 200 horse and 137 veterinary sera for the presence of neutralizing antibodies relating to ERAV and ERBV1. One hundred and eighty (90%) and 173 (86%) horse sera neutralized ERAV and ERBV1, respectively. In contrast, only four (2.7%) and five (3.6%) human sera showed weak neutralizing activity to ERAV and ERBV1, respectively. These results indicate that ERAV and ERBV1 are widespread in the Austrian horse population; however, the risk of acquiring zoonotic infection among veterinarians appears low.
KW - Equine rhinitis virus
KW - Neutralization
KW - Seroprevalence
KW - Zoonotic infection
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U2 - 10.1016/j.vetmic.2004.12.029
DO - 10.1016/j.vetmic.2004.12.029
M3 - Article
C2 - 15778036
AN - SCOPUS:15044346105
SN - 0378-1135
VL - 106
SP - 293
EP - 296
JO - Veterinary Microbiology
JF - Veterinary Microbiology
IS - 3-4
ER -