Potential benefits of phytochemicals for abdominal aortic aneurysm

Azar Hosseini, Peter E. Penson, Arrigo F.G. Cicero, Jonathan Golledge, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar*

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةReview articleمراجعة النظراء

13 اقتباسات (Scopus)

ملخص

Background: Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair. Objec-tive: This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA. Methods: In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised. Results: Some preliminary data support the further investigation of curcumin, radix astra-gali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Sal-vianolic acid as potential treatments for AAA. Conclusion: Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treat-ments, adequately designed double-blind randomized clinical trials will be required.

اللغة الأصليةEnglish
الصفحات (من إلى)8595-8607
عدد الصفحات13
دوريةCurrent Medicinal Chemistry
مستوى الصوت28
رقم الإصدار41
تاريخ مبكر على الإنترنتيونيو 14 2021
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يونيو 14 2021

ASJC Scopus subject areas

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