Polyphenols and Huntington's disease

Huntington's disease is the most common neurodegenerative disease, characterized by notable cognitive impairment and specific movement disorder. Currently used medications offer symptomatic relief to HD, without preventing the disease progression. Various pre-clinical experiments and clinical trials have shown that the multi-target ability of the traditional herbal medicine and its phytochemicals could offer therapeutic ailment for HD. Plant derived polyphenols are the ubiquitous compound with multiple pharmacological activities including antioxidant, anti-inflammatory, mitochondrial protective and anti-apoptotic activities. They can improve cognitive functions and prevent/delay the onset of certain neurodegenerative disease including HD.