TY - JOUR
T1 - Pharmacokinetics of antipyrine and sulphadimidine (sulfamethazine) in camels, sheep and goats
AU - ELSHEIKH, H. A.
AU - ALI, B. H.
AU - HOMEIDA, A. M.
AU - HASSAN, T.
AU - HAPKE, H. J.
PY - 1991/9
Y1 - 1991/9
N2 - The pharmacokinetics of antipyrine and sulphadimidine were studied in male camels, sheep and goats. The two drugs were administered concomitantly. Following intravenous injection of antipyrine (25 mg/kg) and sulphadimidine (sulfamethazine) (100 mg/kg), the pharmacokinetics of the two drugs were adequately described by a one‐compartment model. Antipyrine half‐life in goats (2.58 h) was shorter than that in sheep (4.04 h) and camels (18.78 h). The plasma clearance was greatest in goats then sheep and then camels. For sulphadimidine, a significantly greater volume of distribution was observed in camels and the greatest plasma clearance and shortest half‐life were reported in goats. Sulphadimidine half‐life was 2.77 h in goats, 4.72 h in sheep and 7.36 h in camels. The present results suggest that goats have the fastest elimination of these drugs from the circulation, followed by sheep and then camels.
AB - The pharmacokinetics of antipyrine and sulphadimidine were studied in male camels, sheep and goats. The two drugs were administered concomitantly. Following intravenous injection of antipyrine (25 mg/kg) and sulphadimidine (sulfamethazine) (100 mg/kg), the pharmacokinetics of the two drugs were adequately described by a one‐compartment model. Antipyrine half‐life in goats (2.58 h) was shorter than that in sheep (4.04 h) and camels (18.78 h). The plasma clearance was greatest in goats then sheep and then camels. For sulphadimidine, a significantly greater volume of distribution was observed in camels and the greatest plasma clearance and shortest half‐life were reported in goats. Sulphadimidine half‐life was 2.77 h in goats, 4.72 h in sheep and 7.36 h in camels. The present results suggest that goats have the fastest elimination of these drugs from the circulation, followed by sheep and then camels.
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U2 - 10.1111/j.1365-2885.1991.tb00837.x
DO - 10.1111/j.1365-2885.1991.tb00837.x
M3 - Article
C2 - 1744936
AN - SCOPUS:0025939838
SN - 0140-7783
VL - 14
SP - 269
EP - 275
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
IS - 3
ER -