TY - JOUR
T1 - Paliperidone palmitate-induced delirium in an adolescent with schizophrenia
T2 - Case report
AU - Mirza, Hassan
AU - Harding, Duncan
AU - Al-Balushi, Naser
N1 - Publisher Copyright:
© 2018, Sultan Qaboos University. All rights reserved.
PY - 2018/5
Y1 - 2018/5
N2 - Schizophrenia is a serious long-term mental disorder which usually presents in adolescence or early adulthood. However, poor adherence to oral antipsychotics can lead to relapse and rehospitalisation. We report an adolescent male with schizophrenia who was referred to the South London & Maudsley National Health Service Foundation Trust, London, UK, in 2015 due to worsening psychotic symptoms. Following poor compliance with oral medications, a four-week regimen of paliperidone palmitate long-acting injections was initiated, with an initial positive response. However, 10 days after the second dose, the patient developed severe acute-onset delirium with fluctuating levels of consciousness. Paliperidone palmitate was discontinued and the patient instead underwent a course of zuclopenthixol decanoate long-acting injections with a favourable outcome.
AB - Schizophrenia is a serious long-term mental disorder which usually presents in adolescence or early adulthood. However, poor adherence to oral antipsychotics can lead to relapse and rehospitalisation. We report an adolescent male with schizophrenia who was referred to the South London & Maudsley National Health Service Foundation Trust, London, UK, in 2015 due to worsening psychotic symptoms. Following poor compliance with oral medications, a four-week regimen of paliperidone palmitate long-acting injections was initiated, with an initial positive response. However, 10 days after the second dose, the patient developed severe acute-onset delirium with fluctuating levels of consciousness. Paliperidone palmitate was discontinued and the patient instead underwent a course of zuclopenthixol decanoate long-acting injections with a favourable outcome.
KW - Adolescent Psychiatry
KW - Antipsychotic Agents
KW - Case Report
KW - Delirium
KW - Paliperidone Palmitate
KW - Schizophrenia
KW - United Kingdom
KW - Zuclopenthixol
UR - http://www.scopus.com/inward/record.url?scp=85053438901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053438901&partnerID=8YFLogxK
U2 - 10.18295/squmj.2018.18.02.014
DO - 10.18295/squmj.2018.18.02.014
M3 - Article
C2 - 30210852
AN - SCOPUS:85053438901
SN - 2075-051X
VL - 18
SP - e208-e210
JO - Sultan Qaboos University Medical Journal
JF - Sultan Qaboos University Medical Journal
IS - 2
ER -