TY - JOUR
T1 - Multiple cycles of rituximab therapy in chronic refractory immune thrombocytopenia
T2 - A case report with a 10-year follow-up
AU - Routy, Bertrand
AU - Boulassel, Mohamed Rachid
AU - Spurll, Gwendoline M.
AU - Warner, Margaret N.
AU - Routy, Jean Pierre
PY - 2013/3
Y1 - 2013/3
N2 - Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated low platelet counts often leading to mucocutaneous bleeding. Administration of rituximab was shown to increase platelet counts in patients relapsing chronic ITP. However, duration of response with rituximab and the long-term benefit remains unknown. Herein, the authors presented a case of a 36-year-old splenectomised man with a relapsing ITP who received a total of 10 cycles of rituximab over the last decade with the concomitant assessments of circulating B cells. The data show that rituximab can be an effective therapy over 10 years, and monitoring B cells may help to herald ITP recurrence.
AB - Immune thrombocytopenia (ITP) is an autoimmune disease characterized by isolated low platelet counts often leading to mucocutaneous bleeding. Administration of rituximab was shown to increase platelet counts in patients relapsing chronic ITP. However, duration of response with rituximab and the long-term benefit remains unknown. Herein, the authors presented a case of a 36-year-old splenectomised man with a relapsing ITP who received a total of 10 cycles of rituximab over the last decade with the concomitant assessments of circulating B cells. The data show that rituximab can be an effective therapy over 10 years, and monitoring B cells may help to herald ITP recurrence.
KW - B cells
KW - Immune thrombocytopenia
KW - Platelets
KW - Rituximab
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UR - http://www.scopus.com/inward/citedby.url?scp=84875194598&partnerID=8YFLogxK
U2 - 10.1097/MJT.0b013e318258905e
DO - 10.1097/MJT.0b013e318258905e
M3 - Article
C2 - 23466621
AN - SCOPUS:84875194598
SN - 1075-2765
VL - 20
SP - 219
EP - 222
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
IS - 2
ER -