TY - JOUR
T1 - Modeling and sensitivity analysis of acoustic release of boxorubicin from unstabilized pluronic P105 using an artificial neural network model
AU - Husseini, Ghaleb A.
AU - Abdel-Jabbar, Nabil M.
AU - Mjalli, Farouq S.
AU - Pitt, William G.
PY - 2007/2
Y1 - 2007/2
N2 - This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN), Previously collected release data were compiled and used to train, validate, and test an ANN model. Sensitivity analysis was then performed on the following operating conditions: ultrasonic frequency, power density, Pluronic P105 concentration, and temperature. The model showed that drug release was most efficient at lower frequencies. The analysis also demonstrated that release increases as the power density increases. Sensitivity plots of ultrasound intensity revealed a drug release threshold of 0.015 W/cm2 and 0.38 W/cm2 at 20 and 70 kHz, respectively. The presence of a power density threshold provides strong evidence that cavitation plays an important role in acoustically activated drug release from polymeric micelles. Based on the developed model, Dox release is not a strong function of temperature, suggesting that thermal effects do not play a major role in the physical mechanism involved. Finally, sensitivity plots of P105 concentration indicated that higher release was observed at lower copolymer concentrations.
AB - This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN), Previously collected release data were compiled and used to train, validate, and test an ANN model. Sensitivity analysis was then performed on the following operating conditions: ultrasonic frequency, power density, Pluronic P105 concentration, and temperature. The model showed that drug release was most efficient at lower frequencies. The analysis also demonstrated that release increases as the power density increases. Sensitivity plots of ultrasound intensity revealed a drug release threshold of 0.015 W/cm2 and 0.38 W/cm2 at 20 and 70 kHz, respectively. The presence of a power density threshold provides strong evidence that cavitation plays an important role in acoustically activated drug release from polymeric micelles. Based on the developed model, Dox release is not a strong function of temperature, suggesting that thermal effects do not play a major role in the physical mechanism involved. Finally, sensitivity plots of P105 concentration indicated that higher release was observed at lower copolymer concentrations.
KW - Artificial neural networks
KW - Doxorubicin
KW - Polymeric micelles
KW - Ultrasonic stimulus
KW - and Pluronic P105
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U2 - 10.1177/153303460700600107
DO - 10.1177/153303460700600107
M3 - Article
C2 - 17241100
AN - SCOPUS:33847732277
SN - 1533-0346
VL - 6
SP - 49
EP - 56
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 1
ER -