Metabolic normalization of α-ketoglutarate against N-nitrosodiethylamine-induced hepatocarcinogenesis in rats

K. B. Dakshayani, P. Subramanian*, T. Manivasagam, M. Mohamed Essa

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةArticleمراجعة النظراء

9 اقتباسات (Scopus)

ملخص

Chemoprevention of cancer is one of the reliable approaches to control the incidence of cancer. In the present study, we investigated the chemopreventive role of α-ketoglutarate (α-KG) during N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis. The activities of serum aspartate and alanine transaminases were found to be significantly higher in NDEA + CCl 4-treated animals when compared with control animals. Administration of α-KG restored the activities of transaminases to near normal range. The levels of lipid peroxides, thiobarbituric acid reactive substances were decreased in the liver tissue of NDEA + CCl4-treated animals when compared with control animals. α-KG reversed the lipid peroxide levels to near normal range. Levels of antioxidants, reduced glutathione and activities of its dependent enzymes, glutathione peroxidase and glutathione-S-transferase were found to be significantly higher in liver tissue of NDEA + CCl 4-treated animals when compared with control animals. α-KG administration positively modulated the antioxidant levels to near normal range. In conclusion, it can be suggested that α-KG exerts chemopreventive role which may attributable to its ability to positively modulate the transaminase activities and oxidant-antioxidant imbalance during hepatocarcinogenesis.

اللغة الأصليةEnglish
الصفحات (من إلى)477-480
عدد الصفحات4
دوريةFundamental and Clinical Pharmacology
مستوى الصوت20
رقم الإصدار5
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أكتوبر 2006
منشور خارجيًانعم

ASJC Scopus subject areas

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