Levetiracetam induced weight loss in two children

Two children with refractory seizures had significant weight loss on addition of levetiracetam. Despite improved seizure control, we had to withdraw levetiracetam. Withdrawal of the drug resulted in gradual improvement of weight. Similar findings were reported in adult patients. Although, levetiracetam is generally believed not to affect weight, these recent reports indicate that this drug has the potential of inducing considerable weight loss in both adults and children. Parents need to be warned about this potential side effect.