TY - JOUR
T1 - Leptinemia among obese Omani adults newly diagnosed with type 2 diabetes mellitus
T2 - A case-control study
AU - Waly, Mostafa I.
AU - Ali, Amanat
AU - Al-Farsi, Yahya M.
AU - Bhatt, Neeru
AU - Al-Kilani, Hashim
AU - Ouhtit, Allal
AU - Al-Maskari, Masoud Y.
PY - 2013
Y1 - 2013
N2 - Leptinemia is associated with obesity and obesity and hyperinsulinemia are considered as the main etiological factors for type 2 diabetes mellitus (T2DM) among adult subjects. The present case-control study evaluated the dietaiy pattern and biochemical profile of newly diagnosed T2DM obese Omani adults as compared to their age, weight and gender matched control subjects. Two hundred Omani adults (100 obese adults newly diagnosed with T2DM and 100 healthy controls) were included in this study. Dietaiy intake, body mass index and biochemical measurements for fasting serum glucose, insulin, leptin and blood glycated hemoglobin levels were evaluated for all study participants. Subjects with T2DM showed significantly (p<0.05) higher daily intake of total fats, carbohydrates and energy as compared to controls. Leptinemia and hyperinsulinemia were common among obese diabetic adults as compared to controls. The mean fasting serum levels of glucose and glycated hemoglobin in obese diabetic subjects were significantly (p<0.05) higher than controls. Serum leptin level was found to be positively correlated with body mass index, serum insulin level and total energy intake in all the study subjects. Our results suggest that leptinemia is a risk factor for T2DM in obese Omani adults.
AB - Leptinemia is associated with obesity and obesity and hyperinsulinemia are considered as the main etiological factors for type 2 diabetes mellitus (T2DM) among adult subjects. The present case-control study evaluated the dietaiy pattern and biochemical profile of newly diagnosed T2DM obese Omani adults as compared to their age, weight and gender matched control subjects. Two hundred Omani adults (100 obese adults newly diagnosed with T2DM and 100 healthy controls) were included in this study. Dietaiy intake, body mass index and biochemical measurements for fasting serum glucose, insulin, leptin and blood glycated hemoglobin levels were evaluated for all study participants. Subjects with T2DM showed significantly (p<0.05) higher daily intake of total fats, carbohydrates and energy as compared to controls. Leptinemia and hyperinsulinemia were common among obese diabetic adults as compared to controls. The mean fasting serum levels of glucose and glycated hemoglobin in obese diabetic subjects were significantly (p<0.05) higher than controls. Serum leptin level was found to be positively correlated with body mass index, serum insulin level and total energy intake in all the study subjects. Our results suggest that leptinemia is a risk factor for T2DM in obese Omani adults.
KW - Dietaiy pattern
KW - Leptin
KW - Obesity
KW - Omani adults
KW - Type 2 diabetes mellitus
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U2 - 10.3923/jms.2013.208.214
DO - 10.3923/jms.2013.208.214
M3 - Article
AN - SCOPUS:84878039975
SN - 1682-4474
VL - 13
SP - 208
EP - 214
JO - Journal of Medical Sciences (Faisalabad)
JF - Journal of Medical Sciences (Faisalabad)
IS - 3
ER -
