Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

Marvin Edeas*, Jumana Saleh, Carole Peyssonnaux

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

96 اقتباسات (Scopus)

ملخص

The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the continents with rapidly increasing mortality rates. Current management of COVID-19 is based on the premise that respiratory failure is the leading cause of mortality. However, mounting evidence links accelerated pathogenesis in gravely ill COVID-19 patients to a hyper-inflammatory state involving a cytokine storm. Several components of the heightened inflammatory state were addressed as therapeutic targets. Another key component of the heightened inflammatory state is hyper-ferritinemia which reportedly identifies patients with increased mortality risk. In spite of its strong association with mortality, it is not yet clear if hyper-ferritinemia in COVID-19 patients is merely a systemic marker of disease progression, or a key modulator in disease pathogenesis. Here we address implications of a possible role for hyper-ferritinemia, and altered iron homeostasis in COVID-19 pathogenesis, and potential therapeutic targets in this regard.

اللغة الأصليةEnglish
الصفحات (من إلى)303-305
عدد الصفحات3
دوريةInternational Journal of Infectious Diseases
مستوى الصوت97
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2020

ASJC Scopus subject areas

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بصمة

أدرس بدقة موضوعات البحث “Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?'. فهما يشكلان معًا بصمة فريدة.

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