ملخص
Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.
اللغة الأصلية | English |
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الصفحات (من إلى) | 3868-3871 |
عدد الصفحات | 4 |
دورية | Angewandte Chemie - International Edition |
مستوى الصوت | 53 |
رقم الإصدار | 15 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - أبريل 7 2014 |
ASJC Scopus subject areas
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