TY - JOUR
T1 - Iridium-Catalyzed Borylation of 6-Fluoroquinolines
T2 - Access to 6-Fluoroquinolones
AU - Hickey, Aobha
AU - Merz, Julia
AU - Al Mamari, Hamad H.
AU - Friedrich, Alexandra
AU - Marder, Todd B.
AU - McGlacken, Gerard P.
N1 - Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/7/15
Y1 - 2022/7/15
N2 - The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone-the core structure of many antibiotics.
AB - The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone-the core structure of many antibiotics.
KW - Boron Compounds/chemistry
KW - Catalysis
KW - Fluoroquinolones
KW - Iridium/chemistry
KW - Molecular Structure
UR - http://www.scopus.com/inward/record.url?scp=85135565424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85135565424&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/4516644f-7bf5-34dc-8304-e357ee95d1b3/
U2 - 10.1021/acs.joc.2c00973
DO - 10.1021/acs.joc.2c00973
M3 - Article
C2 - 35839386
AN - SCOPUS:85135565424
SN - 0022-3263
VL - 87
SP - 9977
EP - 9987
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 15
ER -