Investigating the interactions of hyaluronan derivatives with biomolecules. The use of diffusional NMR techniques

Anna Taglienti, Francesco Cellesi, Vittorio Crescenzi, Paolo Sequi, Massimiliano Valentini*, Nicola Tirelli

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

16 اقتباسات (Scopus)

ملخص

The interactions between a biomaterial and biomolecules present in body fluids often determine the fate of the biomaterial. This paper presents a study on hyaluronan (HA)-containing materials (in soluble or colloidal form) that focuses on their interactions with lipids and proteins and for the first time uses PFG NMR as an analytical technique for probing these events. The interactions of HA-based polymers with phospholipids (DPPC and DPPG liposomes) are shown to depend both on charge and hydrophobicity factors. Despite the difference in behavior between albumin (substantially non-adhesive) and fibrinogen (adhesive), the interactions of the polymers with proteins do not seem to be based on hydrophobic effects but on surface polar interactions.

اللغة الأصليةEnglish
الصفحات (من إلى)611-622
عدد الصفحات12
دوريةMacromolecular Bioscience
مستوى الصوت6
رقم الإصدار8
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 7 2006
منشور خارجيًانعم

ASJC Scopus subject areas

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بصمة

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